4-(2-Methyl-4-nitrophenoxy)piperidine hydrochloride CAS 138227-67-5
| CAS No. | 138227-67-5 |
| Molecular Formula | C12H16N2O3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
4-(2-Methyl-4-nitrophenoxy)piperidine hydrochloride (CAS 138227-67-5), molecular formula C12H16N2O3HCl and molecular weight 272.73 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(2-Methyl-4-nitrophenoxy)piperidine hydrochloride (C12H16N2O3HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 4-(2-Methyl-4-nitrophenoxy)piperidine hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16N2O3 HCl |
| Molecular Weight | 272.73 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Methyl Standards
- methyl 1-[(2-nitrophenoxy)methyl]-1H-pyrazole-3-carboxylate (CAS 1003988-83-7)
- 1-((2-Nitrophenoxy)methyl)-1h-pyrazole-3-carboxylic acid (CAS 1004643-30-4)
- 1-((2-Nitrophenoxy)methyl)-1h-pyrazole-3-carbohydrazide (CAS 1004643-35-9)
- 1-((5-Methyl-2-nitrophenoxy)methyl)-1h-pyrazole-3-carboxylic acid (CAS 1006436-24-3)
- 1-((4-Nitrophenoxy)methyl)-1H-pyrazole-3-carboxylic acid (CAS 1006954-05-7)
- 3-(4-Nitrophenoxy)propan-1-amine hydrochloride (CAS 100840-64-0)
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Recommended Standards
- N-Heptatriacontane (CAS 7194-84-5)
- 6-(4-Bromo-2,5-difluorophenoxy)hexanenitrile (CAS 1443337-17-4)
- (R)-N-(Piperidin-3-yl)isobutyramide hydrochloride (CAS 1286207-24-6)
- (5-Chloro-3-(trifluoromethyl)pyridin-2-yl)(methyl)-λ4-sulfanimine 2,4,6-trimethylbenzenesulfonate (CAS 175203-07-3)
- 4-Chloro-1-isobutyl-6-methyl-1h-pyrazolo[3,4-d]pyrimidine (CAS 1094315-28-2)
- Dimethyl(2-nitrophenyl)phosphine oxide (CAS 56964-01-3)
- Repaglinide impurity 27 (CAS CATO-C4X-118627)
- 4-(Benzo[d]thiazol-2-yl)butanenitrile (CAS 21344-52-5)
- Ethylene Glycol monostearate (CAS 111-60-4)
- D-Leu14-Tirzepatide (CAS CATO-CPTD788920)
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