2-(Chloromethyl)-5-fluorothiophene CAS 1384164-41-3
| CAS No. | 1384164-41-3 |
| Molecular Formula | C5H4ClFO |
| Molecular Weight | 134.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(Chloromethyl)-5-fluorothiophene is closely related to a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 2-(Chloromethyl)-5-fluorothiophene (CAS 1384164-41-3), a certified reference material (molecular formula C5H4ClFO, MW 134.54 g/mol) for analytical method development and quality control.
The molecular framework of 2-(Chloromethyl)-5-fluorothiophene (C5H4ClFO) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H4ClFO |
| Molecular Weight | 134.54 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
Related Chloromethyl Standards
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- trans-2-(chloromethyl)cyclopropanecarboxylic acid (CAS 881649-76-9)
- 2512AE 39928-72-8 5-(Chloromethyl)dihydrofuran-2(3H)-one C5H7ClO2 (CAS 39928-72-8)
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Recommended Standards
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- 1-Bromo-7-chloronaphthalene (CAS 29016-72-6)
- Phosphinous amide, N-[(1S)-2′-amino-3,3′-dibromo-4,4′,6,6′-tetrakis(trifluoromethyl)[1,1′-biphenyl]-2-yl]-P,P-diphenyl- (CAS 1093238-03-9)
- Methyl 1-isopropyl-1H-pyrazole-4-carboxylate (CAS 1314965-56-4)
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- 3-(Aminomethyl)-5-methylindolin-2-one (CAS 1071931-87-7)
- Peptide YY (3-36) (canine, mouse, porcine, rat) trifluoroacetate salt (CAS 126339-09-1)
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