(S)-5-(Trifluoromethyl)-2,3-dihydrobenzofuran-3-amine hydrochloride CAS 1384268-68-1
| CAS No. | 1384268-68-1 |
| Molecular Formula | C9H8F3NO |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (S)-5-(Trifluoromethyl)-2,3-dihydrobenzofuran-3-amine hydrochloride.
(S)-5-(Trifluoromethyl)-2,3-dihydrobenzofuran-3-amine hydrochloride (CAS 1384268-68-1) is a high-purity analytical reference standard with the molecular formula C9H8F3NOHCl and a molecular weight of 239.62 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, (S)-5-(Trifluoromethyl)-2,3-dihydrobenzofuran-3-amine hydrochloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 239.62 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8F3NO HCl |
| Molecular Weight | 239.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related S Standards
- 3-(4-(Trifluoromethyl)phenyl)pyrrolidin-3-ol hydrochloride (CAS 1000198-74-2)
- 3-(4-(Trifluoromethyl)phenyl)pyrrolidine (CAS 1000198-76-4)
- (2-Methyl-4-(trifluoromethyl)thiazol-5-yl)methanol (CAS 1000339-72-9)
- methyl 3-((4-(trifluoromethyl)piperidin-1-yl)methyl)benzoate (CAS 1000339-86-5)
- methyl 4-(2-(4-(trifluoromethyl)piperidin-1-yl)ethoxy)benzoate (CAS 1000339-87-6)
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- 3-(2-(4-(trifluoromethyl)piperidin-1-yl)ethyl)benzaldehyde (CAS 1000339-89-8)
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Recommended Standards
- 2,5-Bis(4-methoxyphenyl)-1,3,4-oxadiazole (CAS 847-39-2)
- 5-Chloro-1,2,3,4-tetrahydroisoquinoline Hydrochloride (CAS 799274-05-8)
- N-(3-(4-Fluorophenyl)-5,7-dimethylpyrido[3,4-e][1,2,4]triazin-8-yl)acetamide (CAS 121845-83-8)
- 1-(Thiophen-2-ylmethyl)-1H-pyrazole-4-carboxylic acid (CAS 1154881-88-5)
- ARS-853 (CAS 1629268-00-3)
- Erdafitinib Impurity 14 (CAS CATO-C4X-261614)
- 4-Bromo-6-chloroquinoline-3-carbonitrile (CAS 1260793-72-3)
- Sertaconazole (CAS 99592-32-2)
- 2-Ethyl-1,3-benzoxazol-5-amine (CAS 204771-75-5)
- Calcium-Like Peptide 3 (CAS 261969-05-5)
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