Cetirizine Impurity 8 CAS 1384888-64-5
| CAS No. | 1384888-64-5 |
| Molecular Formula | C27H37ClN2O8 |
| Molecular Weight | 553.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Cetirizine Impurity 8 (CAS 1384888-64-5, C27H37ClN2O8) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C27H37ClN2O8, Cetirizine Impurity 8 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 553.04 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Cetirizine Impurity 8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C27H37ClN2O8 |
| Molecular Weight | 553.04 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Cetirizine Standards
- Cetirizine impurity 38 (CAS CATO-C4X-158238)
- Cetirizine Impurity 25 (CAS CATO-C4X-158225)
- Cetirizine Impurity 34 (CAS CATO-C4X-158234)
- Cetirizine EP Impurity D (CAS 346451-15-8)
- Cetirizine Impurity 34 (Mixture of Diastereomers) (CAS 1243652-36-9)
- Cetirizine Impurity 18 (CAS CATO-C4X-158218)
- Cetirizine Impurity 39 (CAS CATO-C4X-108339)
- (S)-Cetirizine Propanediol Ester (CAS CATO-C4X-158212)
Recommended Standards
- Levocetirizine Impurity 78 (CAS CATO-C4X-108378)
- Bepotastine Impurity 16 (CAS CATO-C4X-183916)
- Levocetirizine Impurity 71 (CAS CATO-C4X-108371)
- Bis(2,4,6-trichlorophenyl) 2-benzylmalonate (CAS 15781-74-5)
- Mianserin impurity 34 (CAS 38869-02-2)
- Ertugliflozin impurity 33 (CAS 2242891-20-7)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com