5,5-Difluoro-5,8-dihydro-6H-pyrano[3,4-d]pyrimidin-2-amine CAS 1391733-01-9

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5,5-Difluoro-5,8-dihydro-6H-pyrano[3,4-d]pyrimidin-2-amine.

5,5-Difluoro-5,8-dihydro-6H-pyrano[3,4-d]pyrimidin-2-amine (CAS 1391733-01-9), molecular formula C7H7F2N3O and molecular weight 187.15 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 5,5-Difluoro-5,8-dihydro-6H-pyrano[3,4-d]pyrimidin-2-amine (C7H7F2N3O) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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