5-Hydroxypyrazine-2-carboxylic Acid Methyl Ester CAS 13924-95-3
| CAS No. | 13924-95-3 |
| Molecular Formula | C6H6N2O3 |
| Molecular Weight | 154.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Hydroxypyrazine-2-carboxylic Acid Methyl Ester.
5-Hydroxypyrazine-2-carboxylic Acid Methyl Ester (CAS 13924-95-3) is a high-purity analytical reference standard with the molecular formula C6H6N2O3 and a molecular weight of 154.12 g/mol.
The molecular framework of 5-Hydroxypyrazine-2-carboxylic Acid Methyl Ester (C6H6N2O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H6N2O3 |
| Molecular Weight | 154.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
| Nitrogen Atoms | 2 |
Related Hydroxypyrazine Standards
- 5-Hydroxypyrazine-2-carbonyl chloride (CAS 1261490-22-5)
- 3-Hydroxypyrazine-2-carbonyl chloride (CAS 98136-34-6)
- 6-hydroxypyrazine-2-carboxylic acid (CAS 13924-99-7)
- 3-Hydroxypyrazine-2-carboxylic Acid (CAS 20737-42-2)
- 5-Hydroxypyrazine-2-carboxylic acid (CAS 34604-60-9)
- ethyl 5-hydroxypyrazine-2-carboxylate (CAS 54013-03-5)
- N-Hydroxypyrazine-2-carboxamide (CAS 768-06-9)
- 5-hydroxypyrazine-2-carbaldehyde (CAS 1822931-46-3)
Recommended Standards
- 2-Amino-3,4-difluorobenzonitrile (CAS 1384265-40-0)
- Methyl 6-oxo-1,6-dihydropyrazine-2-carboxylate (CAS 13924-98-6)
- 5-Amino-4-hydroxy-nicotinic acid (CAS 1378815-02-1)
- 6-Amino-4-hydroxypicolinic acid (CAS 1393552-65-2)
- Pyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione (CAS 21038-67-5)
- 3-Cyclopropoxy-4-iodopicolinamide (CAS 1243405-91-5)
- 4,6-Dimethoxypyridine-2-sulfonyl chloride (CAS 1393538-94-7)
- N,5-Diphenylimidazo[1,5-a]pyrazin-8-amine (CAS 849199-96-8)
- 3-(2,5-Dimethylbenzyl)pyrrolidin-3-ol (CAS 1340080-11-6)
- 1-(2-Chloro-4-fluorophenyl)ethanamine hydrochloride (CAS 2137857-41-9)
- (2-(Ethylthio)-5-fluorophenyl)methanamine (CAS 1192369-50-8)
- 2-Methyl-1-(pyridine-4-carbonyl)piperazine (CAS 1240581-82-1)
- 2-chloro-N-(pentan-2-yl)propanamide (CAS 1016808-29-9)
- Endo-Gly29-Tirzepatide (CAS CATO-CPTD788685)
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