Zolmitriptan Impurity 34 HCl CAS 139264-57-6
| CAS No. | 139264-57-6 |
| Molecular Formula | C10H13N3O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Zolmitriptan Impurity 34 HCl (CAS 139264-57-6, C10H13N3O2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Zolmitriptan Impurity 34 HCl (C10H13N3O2HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Zolmitriptan Impurity 34 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H13N3O2 HCl |
| Molecular Weight | 243.69 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Zolmitriptan Standards
- Zolmitriptan USP Related Compound H (CAS 1116-77-4)
- Zolmitriptan EP Impurity G-d3 (CAS 1217623-11-4)
- Zolmitriptan-d6 (CAS 1217644-84-2)
- Zolmitriptan Impurity 6 (CAS 1241387-63-2)
- Zolmitriptan Impurity N1 (CAS 1346599-24-3)
- Zolmitriptan Sulfonamide Impurity (CAS 1346602-02-5)
- Zolmitriptan EP Impurity C (CAS 1350928-05-0)
- Zolmitriptan EP Impurity D (CAS 139264-15-6)
Recommended Standards
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- Ethyl 2-(4-nitrobenzamido)-5-phenylthiophene-3-carboxylate (CAS 307536-20-5)
- 2-((5-Benzyl-3-carbamoyl-4-methylthiophen-2-yl)carbamoyl)cyclohexane-1-carboxylic acid (CAS 543695-32-5)
- 6-(2,5-Dimethoxyphenyl)-3-(piperidin-2-yl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 1706458-98-1)
- Ethyl 3-benzamido-2-oxo-6-phenyl-2H-pyran-5-carboxylate (CAS 127143-18-4)
- 6-((3-Fluorobenzyl)oxy)-3,4-dihydronaphthalen-1(2H)-one (CAS 1092349-23-9)
- ([13C6]Leu14)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt (CAS 1802078-39-2)
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