Zolmitriptan Impurity 21 CAS 139264-68-9
| CAS No. | 139264-68-9 |
| Molecular Formula | C10H13N3O2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Zolmitriptan Impurity 21 (CAS 139264-68-9) is a certified pharmaceutical impurity reference standard with the molecular formula C10H13N3O2HCl and a molecular weight of 243.69 g/mol.
The molecular framework of Zolmitriptan Impurity 21 (C10H13N3O2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H13N3O2 HCl |
| Molecular Weight | 243.69 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Zolmitriptan Standards
- Zolmitriptan USP Related Compound H (CAS 1116-77-4)
- Zolmitriptan EP Impurity G-d3 (CAS 1217623-11-4)
- Zolmitriptan-d6 (CAS 1217644-84-2)
- Zolmitriptan Impurity 6 (CAS 1241387-63-2)
- Zolmitriptan Impurity N1 (CAS 1346599-24-3)
- Zolmitriptan Sulfonamide Impurity (CAS 1346602-02-5)
- Zolmitriptan EP Impurity C (CAS 1350928-05-0)
- Zolmitriptan EP Impurity D (CAS 139264-15-6)
Recommended Standards
- Pemetrexed impurity 47 (CAS CATO-C4X-172647)
- Urapidil Impurity 17 (CAS 34661-85-3)
- Sofosbuvir Impurity 91 (CAS 817204-35-6)
- 6-Chloro-8-methoxy-2-methylquinolin-4-amine (CAS 1189107-59-2)
- 5631-68-5 A830997 N-methyl-3-nitro-4-pyridinamine N-methyl-3-nitro-pyridin-4-amine (CAS 5631-68-5)
- Methyl 4-amino-1-propyl-1H-pyrazole-3-carboxylate (CAS 1700183-72-7)
- 2,6-Dichloro-4-(methylthio)benzaldehyde (CAS 616196-04-4)
- 6-Ethyl-4-(7-methoxybenzofuran-2-yl)-2H-chromen-2-one (CAS 637753-46-9)
- 4-Iodo-1-((tetrahydro-2H-pyran-4-yl)methyl)-1H-pyrazole (CAS 1266114-25-3)
- GnRH Associated Peptide (GAP) (1-13), human (CAS 100111-07-7)
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