4-(4-Trifluoromethyl-piperidin-1-yl)-butyronitrile CAS 1394652-48-2
| CAS No. | 1394652-48-2 |
| Molecular Formula | C10H15F3N2 |
| Molecular Weight | 220.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-(4-Trifluoromethyl-piperidin-1-yl)-butyronitrile (CAS 1394652-48-2), molecular formula C10H15F3N2 and molecular weight 220.23 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 4-(4-Trifluoromethyl-piperidin-1-yl)-butyronitrile (C10H15F3N2) contains a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 3.0, corresponding to approximately 3 ring(s) or double-bond equivalent(s). With a molecular weight of 220.23 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H15F3N2 |
| Molecular Weight | 220.23 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
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- tert-Butyl N-[2-amino-2-(3-methoxyphenyl)ethyl]carbamate (CAS 912762-85-7)
- 5,6-Difluoro-1,2,3,4-tetrahydroquinoline-2-carboxylic acid (CAS 1706428-68-3)
- 4-Amino-3-chloro-n-methylbenzamide (CAS 408316-92-7)
- Catalponol methylthiomethyl ether (CAS 1432057-74-3)
- 1,2-Bis(4-chlorobenzyl)disulfane (CAS 23566-17-8)
- Edoxaban impurity 129 (CAS CATO-C4X-1063129)
- Ethyl 7-chloro-1H-pyrrolo[3,2-b]pyridine-3-carboxylate (CAS 1419101-46-4)
- Semaglutide Impurity 13 (CAS CATO-C4X-222613)
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