Agomelatine Impurity 14 CAS 139525-77-2
| CAS No. | 139525-77-2 |
| Molecular Formula | C13H15NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Agomelatine Impurity 14 (C13H15NOHCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Agomelatine Impurity 14 (CAS 139525-77-2, C13H15NOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H15NO HCl |
| Molecular Weight | 237.73 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Agomelatine Standards
- Agomelatine-D3 (CAS 107389-38-0)
- Agomelatine-d6 (CAS 1079389-42-6)
- Agomelatine-d4 (CAS 1079389-44-8)
- Agomelatine Impurity 33 (CAS 1079774-32-5)
- Agomelatine Hydrochloride (CAS 1176316-99-6)
- Agomelatine Impurity 36 (CAS 127299-26-7)
- Agomelatine Impurity 19 (CAS 1352139-51-5)
- Agomelatine Impurity 18 (CAS 1352303-07-1)
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- Oxybutynin Impurity 7 (CAS CATO-C4X-19727)
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