2-Chloro-4-fluoro-5-nitroaniline CAS 139626-20-3
| CAS No. | 139626-20-3 |
| Molecular Formula | C6H4ClFN2O2 |
| Molecular Weight | 190.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-Chloro-4-fluoro-5-nitroaniline (CAS 139626-20-3), a certified reference material (molecular formula C6H4ClFN2O2, MW 190.56 g/mol) for analytical method development and quality control.
The molecular framework of 2-Chloro-4-fluoro-5-nitroaniline (C6H4ClFN2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-4-fluoro-5-nitroaniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4ClFN2O2 |
| Molecular Weight | 190.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-Chloro-5-fluoro-4-methyl-3-nitropyridine (CAS 1003711-51-0)
- 5-Chloro-4-fluoro-2-nitroaniline (CAS 104222-34-6)
- 3-Chloro-4-fluoro-2-nitroaniline (CAS 1059081-23-0)
- 5-Chloro-3-fluoro-2-nitroaniline (CAS 1352457-23-8)
- 2-Chloro-5-fluoro-4-hydroxybenzoic acid (CAS 1394954-06-3)
- Methyl 2-Chloro-5-fluoropyrimidine-4-carboxylate (CAS 1404364-32-4)
- 4-Chloro-2-fluoro-6-nitroaniline (CAS 1482558-25-7)
- 2-Chloro-4-fluoro-6-nitroaniline (CAS 153505-32-9)
Recommended Standards
- 4-Chloro-3-fluoro-2-hydroxybenzoic acid (CAS 1702676-05-8)
- 3-Chloro-6-fluoro-2-hydroxybenzoic acid (CAS 1784624-98-1)
- 3-(2-Chloro-1,1,2-trifluoroethoxy)-1,2-propeneoxide (CAS 122502-50-5)
- 4-Chloro-5-fluoro-2-hydroxybenzoic acid (CAS 181289-00-9)
- Ethyl isoxazolo[5,4-c]isoxazole-3-carboxylate (CAS 183666-51-5)
- 1-(Diethoxymethyl)-3-methoxybenzene (CAS 2403-47-6)
- 4-Methyl-5-(trifluoromethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (CAS 51856-10-1)
- methyl[2-(1H-1,2,4-triazol-1-yl)ethyl]amine dihydrochloride (CAS 1461705-94-1)
- N-(6-(4-chlorophenyl)-2-oxo-2H-pyran-3-yl)benzamide (CAS 338747-81-2)
- cis-4-Carbomethoxy-cyclohexane-1-carboxylic acid (CAS 1011-85-4)
- N-((1-((S)-2-Aminopropanoyl)pyrrolidin-3-yl)methyl)-N-isopropylacetamide (CAS 1354032-93-1)
- 5-Acetamido-2,4-dimethylbenzene-1-sulfonyl fluoride (CAS 33866-09-0)
- 2-(4-Chloro-3-ethylphenyl)propan-2-ol (CAS 1379342-47-8)
- Myelin Basic Protein (85-99) Peptide Antagonist (CAS 444305-16-2)
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