2-Chloro-5-ethynylthiophene CAS 139957-82-7
| CAS No. | 139957-82-7 |
| Molecular Formula | C6H3ClS |
| Molecular Weight | 142.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-5-ethynylthiophene.
2-Chloro-5-ethynylthiophene (CAS 139957-82-7) is a high-purity analytical reference standard with the molecular formula C6H3ClS and a molecular weight of 142.61 g/mol.
The molecular framework of 2-Chloro-5-ethynylthiophene (C6H3ClS) is characterized by sulfur-containing functionality, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Chloro-5-ethynylthiophene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H3ClS |
| Molecular Weight | 142.61 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 2-Chloro-3-ethynylthiophene (CAS 1934467-80-7)
- 1-Chloro-2-(methylsulfonyl)ethane (CAS 50890-51-2)
- 2-Chloro-1,4,5,6-tetrahydrocyclopenta[d]imidazole (CAS 1049118-62-8)
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Recommended Standards
- 1-(Chloromethylsulfonyl)ethane (CAS 1728-94-5)
- 3-Chlorobicyclo[3.2.1]oct-2-ene (CAS 35242-17-2)
- Isopropylsulfonyl chloride (CAS 10147-37-2)
- 5-(Chloromethyl)bicyclo[2.2.1]Hept-2-ene (CAS 95-09-0)
- (1R,2S)-2-(3,5-dichlorobenzoyl)cyclohexane-1-carboxylic acid (CAS 844856-68-4)
- Amino-(2-trifluoromethoxy-phenyl)-acetic acid (CAS 1101781-50-3)
- 3-Amino-5-chloroisonicotinic acid (CAS 1256785-41-7)
- ethyl 6-chloro-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylate (CAS 1628946-63-3)
- Methyl N-(3-chlorophenyl)-N-(phenylsulfonyl)glycinate (CAS 591723-37-4)
- 1-(2-(Dimethylamino)ethyl)-5-methyl-1h-pyrazol-3-amine (CAS 1250311-03-5)
- (R)-2-Acetylthio-3-phenylpropionic Acid (CAS 57359-76-9)
- Ethyl 4-methyl-2-(3-nitrophenyl)thiazole-5-carboxylate (CAS 209540-06-7)
- 54640-82-3 Poly(2-Acrylamido-2-Methyl-1-Propanesulfonic Acid-CO-Acrylonitrile) (CAS 54640-82-3)
- Endo-[Glu]31-Liraglutide (CAS CATO-C4X-199234)
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