4-Chloronaphthalene-1,3-diol CAS 1399663-22-9
| CAS No. | 1399663-22-9 |
| Molecular Formula | C10H7ClO2 |
| Molecular Weight | 194.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloronaphthalene-1,3-diol.
4-Chloronaphthalene-1,3-diol (CAS 1399663-22-9), molecular formula C10H7ClO2 and molecular weight 194.61 g/mol, is a CATO reference standard with documented purity and traceability.
4-Chloronaphthalene-1,3-diol (C10H7ClO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H7ClO2 |
| Molecular Weight | 194.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
Related Chloronaphthalene Standards
- 2-Chloronaphthalene-1,4-diol (CAS 73661-09-3)
- 6-Chloronaphthalene-2-thiol (CAS 392330-26-6)
- 5-Chloronaphthalene-1,4-diamine (CAS 144754-08-5)
- 2-Chloronaphthalene-1,8-diamine (CAS 68049-11-6)
- 4-Chloronaphthalene-1,8-diamine (CAS 59841-77-9)
- 4-Chloronaphthalene-1,2-dione (CAS 6655-90-9)
- 5-Chloronaphthalene-1,4-dione (CAS 40242-15-7)
- 8-chloronaphthalene-1-carbaldehyde (CAS 129994-50-9)
Recommended Standards
- 3-Chloro-5-(furan-2-yl)phenol (CAS 1261979-65-0)
- 3-(3-Chloro-2-methylphenyl)propiolic acid (CAS 1403565-36-5)
- 2-Chloro-5-(furan-2-yl)phenol (CAS 1261919-31-6)
- 3-(4-Chloro-2-methylphenyl)propiolic acid (CAS 1403568-21-7)
- Methyl 3-hydroxy-5-oxo-1,2,5,6-tetrahydro-[1,1'-biphenyl]-2-carboxylate (CAS 151777-66-1)
- 2-((tert-Butoxycarbonyl)amino)-3-(2-iodophenyl)propanoic acid (CAS 273221-76-4)
- 2-Methoxy-5-pyridinylboronic Acid (CAS 163105-89-3)
- Bedaquiline impurity 39 (CAS 72543-44-3)
- Methyl 4-cyano-2,5-difluorobenzoate (CAS 200007-66-5)
- Emetine Dihydrochloride (CAS 316-42-7)
- (4-(Trifluoromethyl)piperidin-4-yl)methanol (CAS 1260809-72-0)
- 8-Heptadecene (CAS 16369-12-3)
- 2-Bromo-N-(6-nitrobenzo[d]thiazol-2-yl)acetamide (CAS 1411660-15-5)
- Semaglutide impurity 62 (CAS CATO-C4X-222662)
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