5'-Fluoro-1',4'-dihydro-2'H-spiro[piperidine-4,3'-quinolin]-2'-one hydrochloride CAS 1402232-86-3

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5'-Fluoro-1',4'-dihydro-2'H-spiro[piperidine-4,3'-quinolin]-2'-one hydrochloride.

5'-Fluoro-1',4'-dihydro-2'H-spiro[piperidine-4,3'-quinolin]-2'-one hydrochloride (CAS 1402232-86-3), molecular formula C13H15FN2OHCl and molecular weight 270.73 g/mol, is a CATO reference standard with documented purity and traceability.

Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 5'-Fluoro-1',4'-dihydro-2'H-spiro[piperidine-4,3'-quinolin]-2'-one hydrochloride is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 270.73 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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