3-(4-Bromo-5-methylthiophen-2-yl)propiolic acid CAS 1403565-15-0
| CAS No. | 1403565-15-0 |
| Molecular Formula | C8H5BrO2S |
| Molecular Weight | 245.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 245.09 g/mol gives 3-(4-Bromo-5-methylthiophen-2-yl)propiolic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-(4-Bromo-5-methylthiophen-2-yl)propiolic acid (CAS 1403565-15-0), molecular formula C8H5BrO2S and molecular weight 245.09 g/mol, is a CATO reference standard with documented purity and traceability.
3-(4-Bromo-5-methylthiophen-2-yl)propiolic acid (C8H5BrO2S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(4-Bromo-5-methylthiophen-2-yl)propiolic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5BrO2S |
| Molecular Weight | 245.09 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Br-containing |
| Sulfur Atoms | 1 |
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Recommended Standards
- (2-Bromo-4-fluorophenyl)(cyclopropyl)methanol (CAS 1379329-80-2)
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- 1-Bromo-3-cyclopropylmethoxy-5-fluorobenzene (CAS 1369948-31-1)
- (3-Bromo-2-fluorophenyl)(cyclopropyl)methanol (CAS 1428881-42-8)
- 3,4-Difluoro-2,2-dimethylbutyrophenone (CAS 898766-04-6)
- (S)-1-(Naphthalen-1-ylmethyl)pyrrolidine-2-carboxylic acid hydrochloride (CAS 1217644-88-6)
- Methyl [1-(4-chlorobenzoyl)piperidin-4-YL]acetate (CAS 952905-85-0)
- 5-Chloro-1-methyl-1H-pyrazol-4-amine dihydrochloride (CAS 1989672-54-9)
- 4-(4-Fluorobenzylidene)piperidine (CAS 661452-53-5)
- 4-((3-Bromo-4-methoxybenzylidene)amino)-3-(2-methoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 478257-42-0)
- Deltorphin (CAS 119975-64-3)
- 2-(Chloromethyl)-5-(4-methylphenyl)-1,3,4-oxadiazole (CAS 287197-95-9)
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3'-chloro-[1,1'-biphenyl]-4-yl)propanoic acid (CAS 1380437-47-7)
- Semaglutide impurity 203 (CAS CATO-C4X-2226203)
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