Isopropyl 1-(Boc-amino)-3,3-difluoro-cyclobutanecarboxylate CAS 1403766-72-2
| CAS No. | 1403766-72-2 |
| Molecular Formula | C13H21F2NO4 |
| Molecular Weight | 293.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Isopropyl 1-(Boc-amino)-3,3-difluoro-cyclobutanecarboxylate (CAS 1403766-72-2), molecular formula C13H21F2NO4 and molecular weight 293.31 g/mol, is a CATO reference standard with documented purity and traceability.
Isopropyl 1-(Boc-amino)-3,3-difluoro-cyclobutanecarboxylate (C13H21F2NO4) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H21F2NO4 |
| Molecular Weight | 293.31 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 1-(2,6-Difluorophenyl)-3-(4-(pyrrolidin-1-yl)but-2-yn-1-yl)urea (CAS 1396750-10-9)
- 1-tert-Butyl 2-ethyl 5,5-difluoropiperidine-1,2-dicarboxylate (CAS 1544206-96-3)
- 1-tert-butyl 3-Ethyl 5,5-difluoropiperidine-1,3-dicarboxylate (CAS 1356339-26-8)
- 2-(benzylamino)-1-[3-(difluoromethoxy)phenyl]ethan-1-ol (CAS 1797802-04-0)
- 1-(3-Chloro-2,5-dimethoxyphenyl)-3-(4,6-dimethylpyrimidin-2-yl)guanidine (CAS 1306738-43-1)
- (6-Cyclobutoxy-4-fluoropyridin-3-yl)boronic acid (CAS 2225174-65-0)
- 3-Acetyl-3'-benzyloxybiphenyl (CAS 893736-77-1)
- 1-(4-Ethynylphenyl)-2-methyl-1H-imidazole (CAS 1824572-21-5)
- (2R,3R,4R,5S,6R)-2-(benzyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (CAS 354807-69-5)
- Ethyl 6,8-dichlorooctanoate (CAS 1070-64-0)
- Methyl 4-Hydroxy-5-methoxy-2-nitrobenzoate (CAS 27883-60-9)
- 1-(Cyclohexylethynyl)cyclobutan-1-ol (CAS 1394173-16-0)
- 1-isocyanato-2,3-dimethoxybenzene (CAS 78645-88-2)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
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