2-(5-chlorothiophen-2-yl)-8-fluoro-6-methylquinoline-4-carboxylic acid CAS 1405577-41-4
| CAS No. | 1405577-41-4 |
| Molecular Formula | C15H9ClFNO2S |
| Molecular Weight | 321.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(5-chlorothiophen-2-yl)-8-fluoro-6-methylquinoline-4-carboxylic acid (C15H9ClFNO2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies 2-(5-chlorothiophen-2-yl)-8-fluoro-6-methylquinoline-4-carboxylic acid (CAS 1405577-41-4), a certified reference material (molecular formula C15H9ClFNO2S, MW 321.75 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(5-chlorothiophen-2-yl)-8-fluoro-6-methylquinoline-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H9ClFNO2S |
| Molecular Weight | 321.75 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related chlorothiophen Standards
- N-(5-(5-Chlorothiophen-2-yl)-1,3,4-oxadiazol-2-yl)-2-methylbenzamide (CAS 865543-69-7)
- 2-(5-chlorothiophen-2-yl)-6-methoxyquinoline-4-carboxylic acid (CAS 897565-19-4)
- N-(5-((5-Chlorothiophen-2-yl)methyl)-1,3,4-oxadiazol-2-yl)-5-methylisoxazole-3-carboxamide (CAS 1020978-13-5)
- 2-(5-Chlorothiophen-2-yl)-5,7-dimethylquinoline-4-carboxylic acid (CAS 897558-84-8)
- 2-(5-Chlorothiophen-2-yl)-5,8-dimethylquinoline-4-carboxylic acid (CAS 897554-57-3)
- 2-(5-Chlorothiophen-2-yl)-6,8-dimethylquinoline-4-carboxylic acid (CAS 438229-70-0)
- 2-(5-Chlorothiophen-2-yl)-6-ethylquinoline-4-carboxylic acid (CAS 862654-38-4)
- N-(4-(5-Chlorothiophen-2-yl)thiazol-2-yl)-3-methylisoxazole-5-carboxamide (CAS 946286-03-9)
Recommended Standards
- 4-Chloro-5-(2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl)thiazol-2-amine (CAS 1217486-93-5)
- Methyl (2E)-2-(3-chloro-4-fluorobenzenesulfonyl)-3-(dimethylamino)prop-2-enoate (CAS 1786041-92-6)
- 5-Chloro-1-(phenylsulfonyl)indoline-2,3-dione (CAS 85702-71-2)
- 1-(3-Chloro-4-fluorobenzenesulfonyl)piperidine-4-carboxylic acid (CAS 869472-74-2)
- 5,5-Dimethyl-3-((4-(trifluoromethoxy)phenyl)amino)cyclohex-2-en-1-one (CAS 1023590-22-8)
- 4-chloro-2-(4-chlorophenyl)aniline (CAS 1101170-85-7)
- 4-(Cyclopropylmethoxy)pyrimidine-2-carboxylic acid (CAS 1862409-88-8)
- 2-[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]-N-(4-methoxyphenyl)acetamide (CAS 478042-37-4)
- (2-Bromophenyl)(p-tolyl)methanol (CAS 59142-66-4)
- 6-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyridine (CAS 746667-09-4)
- Tulobuterol Impurity 9 (CAS CATO-C4X-21349)
- (7-Amino-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(2-chlorophenyl)methanone (CAS 164526-16-3)
- (R)-1-(4-Methylbenzyl)pyrrolidine-2-carboxylic acid hydrochloride (CAS 1217789-18-8)
- Exenatide Acetate (CAS 141732-76-5)
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