3-[(2E)-3-(4-Chlorophenyl)prop-2-enoyl]-4-hydroxy-6-methyl-2H-pyran-2-one CAS 14073-08-6
| CAS No. | 14073-08-6 |
| Molecular Formula | C15H11ClO4 |
| Molecular Weight | 290.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-[(2E)-3-(4-Chlorophenyl)prop-2-enoyl]-4-hydroxy-6-methyl-2H-pyran-2-one.
3-[(2E)-3-(4-Chlorophenyl)prop-2-enoyl]-4-hydroxy-6-methyl-2H-pyran-2-one (CAS 14073-08-6) is a high-purity analytical reference standard with the molecular formula C15H11ClO4 and a molecular weight of 290.70 g/mol.
The molecular framework of 3-[(2E)-3-(4-Chlorophenyl)prop-2-enoyl]-4-hydroxy-6-methyl-2H-pyran-2-one (C15H11ClO4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H11ClO4 |
| Molecular Weight | 290.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
Related E Standards
- 2-[N'-(4-Chlorophenyl)hydrazinecarbonyl]benzoic acid (CAS 109187-07-7)
- (Z)-[(4-Chlorophenyl)methyl][(4-nitrophenyl)methylidene]oxidoazanium (CAS 939888-34-3)
- 2-(4-Chlorophenyl)-2-oxoethyl 4-hydroxybenzoate (CAS 386730-85-4)
- 4-(4-Chlorophenyl)-5,7-dihydroxychroman-2-one (CAS 338417-72-4)
- 4-[(4-Chlorophenyl)amino]-2-(dimethylamino)-6-oxo-6H-1,3-oxazine-5-carbonitrile (CAS 303997-23-1)
- N-(2-Chlorophenyl)-2-isonicotinoylhydrazine-1-carboxamide (CAS 904755-29-9)
- 2-((4-Chlorophenyl)thio)-5-nitrobenzonitrile (CAS 78940-73-5)
- 4-((4-Chlorophenyl)thio)-3-nitrobenzonitrile (CAS 27917-77-7)
Recommended Standards
- 6-Chloro-2-(3,4-dimethoxyphenyl)oxazolo[5,4-b]pyridine (CAS 1354750-03-0)
- Methyl 2'-chloro-2-formyl-5'-hydroxy-[1,1'-biphenyl]-3-carboxylate (CAS 1414029-17-6)
- N-(4-Chlorobenzyl)-4-nitrobenzamide (CAS 130780-11-9)
- 2-(3-Chloro-4-methoxybenzoyl)benzoic acid (CAS 158425-76-4)
- 2-((4-Bromo-2,5-dimethylphenyl)thio)-N-(2-hydroxyethyl)acetamide (CAS 1156037-04-5)
- N,N'-(1,3,5-Triazine-2,4-diyl)diacetamide (CAS 5961-78-4)
- (S)-tert-Butyl cyclopropyl((1-(2-hydroxyethyl)pyrrolidin-2-yl)methyl)carbamate (CAS 1354019-40-1)
- 1-methyl-1H-1,2,3-triazole-5-sulfonamide (CAS 1602410-39-8)
- Imidazo[1,2-a]pyridine-3-carbonyl chloride (CAS 750509-02-5)
- 1-(Tert-butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol but-2-enedioate (CAS 1184963-58-3)
- 3-(3-Bromopropyl)-2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic Acid 1,1-Dimethylethyl Ester (CAS 1148017-48-4)
- 2-(1-Benzhydrylazetidin-2-yl)acetonitrile (CAS 92992-32-0)
- N'-((4-Bromothiophen-2-yl)methylene)-2-hydroxybenzohydrazide (CAS 758701-36-9)
- Semaglutide impurity 48 (CAS CATO-C4X-222648)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com