2-(4-(2,3-Difluorophenoxy)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane CAS 1414357-64-4
| CAS No. | 1414357-64-4 |
| Molecular Formula | C18H18BF3O3 |
| Molecular Weight | 350.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
2-(4-(2,3-Difluorophenoxy)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1414357-64-4), molecular formula C18H18BF3O3 and molecular weight 350.14 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-(4-(2,3-Difluorophenoxy)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (C18H18BF3O3) contains a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.5, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 350.14 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-(4-(2,3-Difluorophenoxy)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18BF3O3 |
| Molecular Weight | 350.14 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
Related Difluorophenoxy Standards
- 4-(2,4-Difluorophenoxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS 1446236-84-5)
- N-(6-(2,4-Difluorophenoxy)-1-oxo-2,3-dihydro-1H-inden-5-yl)methanesulfonamide (CAS 80937-31-1)
- N-(2-((3-(3,5-difluorophenoxy)-2-hydroxypropyl)amino)ethyl)morpholine-4-carboxamide (CAS 1638764-33-6)
- N-(2-((3-(2,5-difluorophenoxy)-2-hydroxypropyl)amino)ethyl)morpholine-4-carboxamide (CAS 1638768-67-8)
- N-(2-((3-(2,6-difluorophenoxy)-2-hydroxypropyl)amino)ethyl)morpholine-4-carboxamide (CAS 1638772-26-5)
- N-(6-(2,4-Difluorophenoxy)Indan-5-ylMethanesulfonamide (CAS 81614-86-0)
- 2-(2,4-Difluorophenoxy)-8-methyl-4-(trifluoromethyl)quinoline (CAS 338750-08-6)
- 3-((2,4-Difluorophenoxy)methyl)-5-(4-ethoxy-3-methoxyphenyl)-1H-1,2,4-triazole (CAS 1416346-67-2)
Recommended Standards
- 1-(4-Bromo-2-fluorophenyl)-5-(1h-pyrrol-1-yl)-1h-pyrazole-4-carboxylic acid (CAS 1224155-10-5)
- (2-Chloro-6-(ethoxycarbonyl)phenyl)zinc pivalate ( 0.85 mmol/g) (CAS 1643794-44-8)
- Crisaborole Impurity 37 (CAS CATO-C4X-202137)
- Ethyl 3-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-4-carboxylate (CAS 1190060-37-7)
- 8-Chloro-5-fluoro-2-(trifluoromethyl)quinoline (CAS 1227293-40-4)
- (S)-2-Amino-2-(1-hydroxycyclopropyl)acetic acid (CAS 77448-58-9)
- (6-(Dimethoxymethyl)pyridin-2-yl)boronic acid (CAS 1256355-18-6)
- 6-Methylquinolin-3-amine (CAS 315228-68-3)
- Boron tris(trifluoroacetate), (1M Solution in TFA) (CAS 350-70-9)
- 1-(2-Bromo-ethylsulfanyl)-1,1,2,2,2-pentafluoro-ethane (CAS 1401687-60-2)
- 3-(5-((3-Bromobenzyl)thio)-4-(4-ethoxyphenyl)-4H-1,2,4-triazol-3-yl)pyridine (CAS 585555-96-0)
- 2-(Phenylsulfonyl)propanehydrazide (CAS 886499-82-7)
- (S)-tert-Butyl 2-(2-ethoxy-2-oxoethyl)piperidine-1-carboxylate (CAS 308273-64-5)
- Boc-Cholecystokinin Octapeptide (desulfated) (A-1295.0001) (CAS 25687-34-7)
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