Dronedarone Impurity 18 CAS 141626-26-8
| CAS No. | 141626-26-8 |
| Molecular Formula | C26H34N2O3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Dronedarone Impurity 18 (CAS 141626-26-8), a pharmacopoeial impurity reference standard (molecular formula C26H34N2O3HCl, MW 459.03 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Dronedarone Impurity 18 (C26H34N2O3HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H34N2O3 HCl |
| Molecular Weight | 459.03 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Dronedarone Standards
- Dronedarone Impurity 55 (CAS 100-07-2)
- Dronedarone-D6 (CAS 1132693-87-8)
- Dronedarone Impurity 42 (CAS 113385-32-3)
- Dronedarone Impurity 60 (CAS 1250316-60-9)
- Dronedarone USP Related Compound C (CAS 1278585-68-4)
- Dronedarone Impurity 14 (CAS 1278585-70-8)
- Dronedarone EP Impurity B DiHCl (CAS 1309476-91-2)
- Dronedarone-d6 HCl (CAS 1329809-23-5)
Recommended Standards
- Acetylcysteine Impurity 14 (CAS 62305-89-9)
- Semaglutide impurity 249 (CAS CATO-C4X-2226249)
- Roxadustat Impurity 10 (CAS CATO-C4X-221310)
- tert-Butyl 3-(hydroxymethyl)-4-methoxypyrrolidine-1-carboxylate (CAS 1823438-30-7)
- 3,6-Dibromo-9-phenylcarbazole (CAS 57103-20-5)
- Ethyl 3-cyclohexylpropiolate (CAS 33547-94-3)
- N-(3-Isobutoxybenzyl)-2-propanamine (CAS 1040683-53-1)
- 3-((Ethoxycarbonothioyl)thio)propane-1-sulfonic acid (CAS 34005-00-0)
- 2-Chloro-1-(4-(3-methoxyphenyl)piperazin-1-yl)ethan-1-one (CAS 165751-24-6)
- Semaglutide Impurity 157 (x TFA Salt) (CAS CATO-C4X-2226157)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com