4-Chloro-2-(4-fluorophenyl)-6-nitroquinoline CAS 1416440-17-9
| CAS No. | 1416440-17-9 |
| Molecular Formula | C15H8ClFN2O2 |
| Molecular Weight | 302.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-2-(4-fluorophenyl)-6-nitroquinoline.
4-Chloro-2-(4-fluorophenyl)-6-nitroquinoline (CAS 1416440-17-9), molecular formula C15H8ClFN2O2 and molecular weight 302.69 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 4-Chloro-2-(4-fluorophenyl)-6-nitroquinoline (C15H8ClFN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 302.69 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H8ClFN2O2 |
| Molecular Weight | 302.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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Recommended Standards
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- 1-(2-Aminoethyl)pyrimidin-2(1H)-one dihydrochloride (CAS 2173999-35-2)
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- Piperazine Impurity 17 (CAS CATO-C4X-242717)
- Fmoc-(1S,2S)-2-aminocyclopentane carboxylic acid (CAS 359586-64-4)
- N-(7-Oxo-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)benzo[d]thiazole-2-carboxamide (CAS 1206995-55-2)
- 5-Bromo-N-(2-(p-tolyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl)furan-2-carboxamide (CAS 450340-33-7)
- D-Phe6-Tirzepatide (CAS CATO-CPTD788925)
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