tert-Butyl 4-hydroxy-3,5-dimethylpiperidine-1-carboxylate CAS 1420876-48-7
| CAS No. | 1420876-48-7 |
| Molecular Formula | C12H23NO3 |
| Molecular Weight | 229.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
tert-Butyl 4-hydroxy-3,5-dimethylpiperidine-1-carboxylate (CAS 1420876-48-7), molecular formula C12H23NO3 and molecular weight 229.32 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of tert-Butyl 4-hydroxy-3,5-dimethylpiperidine-1-carboxylate (C12H23NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H23NO3 |
| Molecular Weight | 229.32 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 1 |
Recommended Standards
- (R)-tert-Butyl 2-(hydroxymethyl)-4,4-dimethylpyrrolidine-1-carboxylate (CAS 1417743-45-3)
- Tert-butyl (S)-4-hydroxy-3,3-dimethylpiperidine-1-carboxylate (CAS 1421252-97-2)
- 4-Octanamidobutanoic acid (CAS 140846-94-2)
- Tert-butyl (3R,4S)-4-methoxy-3-methylpiperidine-1-carboxylate (CAS 1421253-15-7)
- 1-(Pyridin-2-ylmethyl)piperidin-4-ol (CAS 914641-83-1)
- 6-Bromo-3-methoxypyridine-2-carboxylic acid, 97% (CAS 1256810-26-0)
- N-(3-bromophenyl)-2-(4-oxo-7-phenylthieno[3,2-d]pyrimidin-3(4H)-yl)acetamide (CAS 1105207-18-8)
- 5-Iodo-2-methylbenzoyl chloride (CAS 108440-70-6)
- Tert-butyl 1-cyano-5-azaspiro[2.5]Octane-5-carboxylate (CAS 1784918-91-7)
- 3-(2-Hydroxyethyl)benzo[d]thiazol-2(3H)-one (CAS 21344-50-3)
- 2-(4,5-Dibromothiophen-2-yl)-1H-benzo[d]imidazole (CAS 49542-35-0)
- 4-Methoxy-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one (CAS 1143575-96-5)
- Boc-trans-DL-β-Pro-4-(3,4-dimethoxyphenyl)-OH (CAS 959580-91-7)
- Insulin Degludec Impurity 18 (CAS CATO-C4X-215718)
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