Levodopa Impurity N1 CAS 1421-65-4
| CAS No. | 1421-65-4 |
| Molecular Formula | C10H14ClNO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 247.67 g/mol gives Levodopa Impurity N1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Levodopa Impurity N1 (CAS 1421-65-4, C10H14ClNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Levodopa Impurity N1 (C10H14ClNO4) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H14ClNO4 |
| Molecular Weight | 247.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Levodopa Standards
- Levodopa Impurity 13 (CAS 1176784-51-2)
- Levodopa Impurity 10 HCl (CAS 144334-59-8)
- Levodopa EP Impurity C (CAS 15402-76-3)
- Levodopa Impurity 14 (CAS 161940-76-7)
- Levodopa Impurity 6 (CAS 18692-68-7)
- Rac-Levodopa EP Impurity A (CAS 21373-30-8)
- Levodopa Impurity 15 (CAS 2323070-48-8)
- Levodopa Impurity 12 (CAS 25520-73-4)
Recommended Standards
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- (S)-tert-Butyl (1-(benzofuran-2-yl)-2-hydroxyethyl)carbamate (CAS 1388664-24-1)
- 3-Cyano-2-(4-methylpiperazinomethyl) benzophenone (CAS 898782-84-8)
- Gastric Inhibitory Polypeptide (human) (CAS 100040-31-1)
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