N-(4-Bromo-2-fluorophenyl)-6-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]thiazine-3-carboxamide CAS 1421584-72-6
| CAS No. | 1421584-72-6 |
| Molecular Formula | C14H11BrFN3O2S |
| Molecular Weight | 384.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(4-Bromo-2-fluorophenyl)-6-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]thiazine-3-carboxamide.
N-(4-Bromo-2-fluorophenyl)-6-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]thiazine-3-carboxamide (CAS 1421584-72-6), molecular formula C14H11BrFN3O2S and molecular weight 384.22 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, N-(4-Bromo-2-fluorophenyl)-6-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]thiazine-3-carboxamide (C14H11BrFN3O2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 384.22 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(4-Bromo-2-fluorophenyl)-6-oxo-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3]thiazine-3-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H11BrFN3O2S |
| Molecular Weight | 384.22 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 2-(((4-(4,5-Dichloro-1H-imidazol-1-yl)phenyl)imino)methyl)-3-hydroxy-1H-inden-1-one (CAS 1024316-38-8)
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- 5-{[(2,4-dichlorophenyl)methylidene]amino}-6-imino-2-oxo-1-phenyl-1,2,3,6-tetrahydropyrimidine-4-carbonitrile (CAS 1020251-99-3)
- N-[6-(4-Bromophenyl)-4-methyl-2-oxo-2H-pyran-3-yl]benzamide (CAS 478067-12-8)
- Methyl 3-methyl-5-(trifluoromethoxy)benzoate (CAS 1261650-22-9)
- 1-(4-Chlorophenyl)-3-((3-fluoropropyl)thio)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (CAS 691868-87-8)
- 4-(4-Bromo-1h-pyrazol-1-yl)-3-fluoroaniline (CAS 1171532-05-0)
- 3-(2,4-Dichlorophenyl)-5-((4-methoxybenzyl)thio)-4H-1,2,4-triazol-4-amine (CAS 676485-00-0)
- Ethyl-L-serine (CAS 83293-50-9)
- Tetrahydropyran-4-boronic acid pinacol ester (CAS 1131912-76-9)
- 1-(6-(2-Chlorophenoxy)pyridin-3-yl)ethanone (CAS 1546175-37-4)
- 3-Fluoro-5-iodopyridin-2(1H)-one (CAS 1806415-83-7)
- 2-(3-Hydroxy-5-nitrophenyl)acetic acid (CAS 1261746-17-1)
- Semaglutide impurity 57 (CAS 2773558-06-6)
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