3-(Difluoromethyl)-3-hydroxypyrrolidine-2-carboxylic acid CAS 1423024-16-1
| CAS No. | 1423024-16-1 |
| Molecular Formula | C6H9F2NO3 |
| Molecular Weight | 181.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies 3-(Difluoromethyl)-3-hydroxypyrrolidine-2-carboxylic acid (CAS 1423024-16-1), a certified reference material (molecular formula C6H9F2NO3, MW 181.14 g/mol) for analytical method development and quality control.
3-(Difluoromethyl)-3-hydroxypyrrolidine-2-carboxylic acid (C6H9F2NO3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C6H9F2NO3 |
| Molecular Weight | 181.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoromethyl Standards
- 2-(Difluoromethyl)-3-methyl-1H-indole (CAS 1379263-70-3)
- 1-(Difluoromethyl)-6-methyl-1H-indole (CAS 1597374-77-0)
- 1-(Difluoromethyl)-4-methyl-1H-indole (CAS 1602204-87-4)
- 2-(Difluoromethyl)-4,5-difluoropyridin-3-ol (CAS 1804453-95-9)
- 5-(Difluoromethyl)furan-2-carbonyl Chloride (CAS 1173834-54-2)
- [4-(difluoromethyl)thiophen-3-yl]boronic acid (CAS 2246874-50-8)
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- 3-(Difluoromethyl)-4,4-dimethylpentanoic acid (CAS 1889667-88-2)
Recommended Standards
- 2-(2-Oxo-2-(phenylamino)ethylidene)-N-phenyloxazolidine-3-carboxamide (CAS 14037-24-2)
- 4-Acetyl-3,5-difluorobenzonitrile (CAS 1523144-23-1)
- 3,6-difluoro-2-nitrophenol (CAS 139548-97-3)
- 4-(Trifluoromethyl)thiazole-5-carbaldehyde (CAS 164294-15-9)
- 4-Oxo-1-phenylpyrrolidine-3-carbonitrile (CAS 23935-47-9)
- 2-(1,5-Dimethyl-1h-pyrrol-2-yl)-1,3-thiazole-4-carboxylic acid (CAS 1423026-00-9)
- 2,5-dichloro-3-(chloromethyl)thiophene (CAS 10095-91-7)
- Tert-butyl n-[2-methyl-1-(methylamino)propan-2-yl]carbamate (CAS 134597-95-8)
- 2'-Amino-6-bromo-4',5'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyde (CAS 477742-53-3)
- trans,trans-4'-Ethyl-4-(3,4,5-trifluorophenyl)bicyclohexyl (CAS 139215-80-8)
- S-Adenosyl-L-Methionine Impurity 32 (CAS CATO-C4X-138132)
- 3-(2,3-Difluorophenyl)azetidine Hydrochloride (CAS 1260870-03-8)
- 2-aminospiro[3.5]nonane-2-carboxylic acid (CAS 1706434-87-8)
- D-Ile27-Tirzepatide (CAS CATO-CPTD788907)
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