2-Amino-5-fluoro-4-hydroxy-quinazoline CAS 142465-05-2
| CAS No. | 142465-05-2 |
| Molecular Formula | C8H6FN3O |
| Molecular Weight | 179.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 2-Amino-5-fluoro-4-hydroxy-quinazoline (CAS 142465-05-2), a certified reference material (molecular formula C8H6FN3O, MW 179.15 g/mol) for analytical method development and quality control.
The molecular framework of 2-Amino-5-fluoro-4-hydroxy-quinazoline (C8H6FN3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6FN3O |
| Molecular Weight | 179.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Amino Standards
- 2-Amino-8-fluoroquinazolin-4(3H)-one (CAS 1379218-75-3)
- 2-Amino-6-fluoro-4H-chromen-4-one (CAS 1934766-63-8)
- 2-amino-7-fluoro-chromen-4-one (CAS 2920919-89-5)
- 4-Amino-6-fluoro-1H-indazole-3-carbaldehyde (CAS 885522-89-4)
- 6-Amino-4-fluoro-1H-indazole-3-carbaldehyde (CAS 885522-65-6)
- 6-amino-7-fluoro-1H-quinoxalin-2-one (CAS 2758437-85-1)
- 6-Amino-7-fluoroquinazolin-4(3H)-one (CAS 877825-72-4)
- 1-Amino-4,4-difluorocyclohexanecarboxylic acid (CAS 1240529-10-5)
Recommended Standards
- 3-Diazenyl-5-fluoro-1h-indol-2-ol (CAS 1401343-77-8)
- 2,5-Dioxopyrrolidine-3-sulfonic acid (CAS 144285-93-8)
- 3-(3-Fluoropyridin-4-yl)isoxazol-5-amine (CAS 1467230-64-3)
- 3-(4-Fluorophenyl)-5-hydroxyisoxazole (CAS 1354939-56-2)
- 3-(Pyrrolidin-2-yl)quinoline (CAS 499207-38-4)
- 7-Ethylindole-3-carbaldehyde (CAS 154989-45-4)
- 1242925-73-0 6-(5-Ethyl-1,2,4-oxadiazol-3-yl)-2-(4-fluorophenyl)-1,2,4-triazine-3,5(2H,4H)-dione MFCD15732334 (CAS 1242925-73-0)
- (S)-1-(3-chloro-5-methoxyphenyl)propan-1-amine (CAS 1336211-37-0)
- Papain (CAS 9001-73-4)
- 6,7-Dihydrocyclopenta[c]pyran-3(5H)-one (CAS 6249-24-7)
- 1-(4-(Dimethylamino)benzyl)pyrrolidin-3-amine (CAS 1247453-24-2)
- 4-Aminopyridine-2-carbothioamide (CAS 1343641-19-9)
- 2-(2-Bromoethyl)-4-chloro-1-methoxybenzene (CAS 14613-38-8)
- (Des-Thr7)-Glucagon trifluoroacetate salt (CAS 1802078-28-9)
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