5-Chloro-3-(4-nitrophenyl)isoxazole CAS 142598-83-2
| CAS No. | 142598-83-2 |
| Molecular Formula | C9H5ClN2O3 |
| Molecular Weight | 224.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Chloro-3-(4-nitrophenyl)isoxazole (CAS 142598-83-2), molecular formula C9H5ClN2O3 and molecular weight 224.60 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Chloro-3-(4-nitrophenyl)isoxazole (C9H5ClN2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-Chloro-3-(4-nitrophenyl)isoxazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5ClN2O3 |
| Molecular Weight | 224.60 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
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- 2-(3-Chloropyridin-2-yl)-2H-1,2,3-triazole-4-carboxylic acid (CAS 1431728-93-6)
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- Ethyl 2,5,6-trichloronicotinate (CAS 2089325-36-8)
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