4-Ethynyl-2,5-difluoropyridine CAS 1426243-94-8
| CAS No. | 1426243-94-8 |
| Molecular Formula | C7H3F2N |
| Molecular Weight | 139.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
4-Ethynyl-2,5-difluoropyridine (CAS 1426243-94-8) is a high-purity analytical reference standard with the molecular formula C7H3F2N and a molecular weight of 139.10 g/mol.
The molecular framework of 4-Ethynyl-2,5-difluoropyridine (C7H3F2N) is characterized by a nitrile group, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 4-Ethynyl-2,5-difluoropyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H3F2N |
| Molecular Weight | 139.10 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ethynyl Standards
- 2-Ethynyl-3,5-difluoropyridine (CAS 1121585-18-9)
- 3-Ethynyl-2,4-difluoropyridine (CAS 1426244-29-2)
- 4-Ethynyl-2,3-difluoropyridine (CAS 1426244-30-5)
- 5-Ethynyl-2,3-difluoropyridine (CAS 1824109-24-1)
- 4-Ethynyl-3,5-difluoropyridine (CAS 1824403-41-9)
- 3-ethynyl-3-hydroxy-1-methylpyrrolidin-2-one (CAS 1202769-93-4)
- (R)-3-Ethynyl-3-hydroxy-1-methylpyrrolidin-2-one, >97% (CAS 1451089-77-2)
- (S)-3-Ethynyl-3-hydroxy-1-methylpyrrolidin-2-one (CAS 1799615-79-4)
Recommended Standards
- 2,2-Difluoro-N-methoxy-N-methylacetamide (CAS 142492-01-1)
- 2,2-Difluoro-3-(methylamino)propanoic acid (CAS 1346746-34-6)
- 4-Amino-2,2-difluorobutanoic acid (CAS 130592-02-8)
- 4-Amino-3,3-difluorobutanoic acid (CAS 1258651-00-1)
- 2-Chloro-5-(chlorosulfonyl)-4-fluorobenzoic acid (CAS 264927-50-6)
- 2-(2-Chloropyridin-3-yl)-1-ethyl-1H-benzo[d]imidazole (CAS 400081-24-5)
- 2,5-dihydrothiophene-3-carboxylic acid (CAS 98508-62-4)
- Methyl 4-methoxypyrazolo[1,5-a]pyridine-3-carboxylate (CAS 1060724-61-9)
- 2-(cyclopropylmethoxy)-2-methylpropan-1-amine hydrochloride (CAS 1909327-11-2)
- 1-(Pyrimidin-2-yl)-1H-imidazol-5(4H)-imine (CAS 88945-45-3)
- 3-(2-(4-Bromophenyl)-2-oxoethyl)-1-methylimidazolidine-2,4-dione (CAS 1031151-09-3)
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- Abemaciclib Impurity 143 (CAS CATO-C4X-2937143)
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