2-(3-Fluoropyridin-2-yl)-1,3-thiazole-4-carboxylic acid CAS 1427380-08-2
| CAS No. | 1427380-08-2 |
| Molecular Formula | C9H5FN2O2S |
| Molecular Weight | 224.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 224.21 g/mol gives 2-(3-Fluoropyridin-2-yl)-1,3-thiazole-4-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
2-(3-Fluoropyridin-2-yl)-1,3-thiazole-4-carboxylic acid (CAS 1427380-08-2), molecular formula C9H5FN2O2S and molecular weight 224.21 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(3-Fluoropyridin-2-yl)-1,3-thiazole-4-carboxylic acid (C9H5FN2O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H5FN2O2S |
| Molecular Weight | 224.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Fluoropyridin Standards
- (2-Fluoropyridin-3-yl)(3-hydroxypiperidin-1-yl)methanone (CAS 1065484-91-4)
- 2-(6-Fluoropyridin-2-yl)quinoline (CAS 1245643-84-8)
- 1-(5-Fluoropyridin-2-yl)piperidine-4-carboxylic acid (CAS 1256792-14-9)
- 1-(4-Fluoropyridin-2-yl)-N,N-dimethylpiperidin-4-amine 1707358-01-7 (CAS 1707358-01-7)
- 1-(5-Fluoropyridin-3-yl)-N,N-dimethylpiperidin-4-amine (CAS 1774896-70-6)
- 1-(5-Fluoropyridin-2-yl)-N,N-dimethylpiperidin-4-amine (CAS 1779120-54-5)
- 1-(3-Fluoropyridin-2-yl)-N,N-dimethylpiperidin-4-amine (CAS 1779127-68-2)
- N-((5-Fluoropyridin-2-yl)methyl)-1-methylpiperidin-4-amine (CAS 1878946-25-8)
Recommended Standards
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- 1-(2-Methoxyethyl)-6-oxo-1,6-dihydropyridine-2-carboxylic acid (CAS 1439900-64-7)
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