2-Chloro-1,1-Bis(4-Chlorophenyl)-2,2-Difluoro-Ethanol CAS 1428-03-1
| CAS No. | 1428-03-1 |
| Molecular Formula | C14H9Cl3F2O |
| Molecular Weight | 337.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
2-Chloro-1,1-Bis(4-Chlorophenyl)-2,2-Difluoro-Ethanol (CAS 1428-03-1), molecular formula C14H9Cl3F2O and molecular weight 337.58 g/mol, is a CATO reference standard with documented purity and traceability.
2-Chloro-1,1-Bis(4-Chlorophenyl)-2,2-Difluoro-Ethanol (C14H9Cl3F2O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H9Cl3F2O |
| Molecular Weight | 337.58 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
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Recommended Standards
- 6-Bromo-4-chloro-2-(4-fluoro-phenyl)-quinazoline (CAS 885277-35-0)
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- 2-(4-Bromo-phenyl)-4-chloro-7-fluoro-quinazoline (CAS 885277-86-1)
- 3,5-Bis(chlorosulfonyl)benzoyl Chloride (CAS 37828-01-6)
- 1-(1,2,4-Trimethyl-1H-imidazol-5-yl)ethanone (CAS 403793-52-2)
- Methyl 5-(5-methyl-1H-pyrazol-3-yl)furan-2-carboxylate (CAS 1224742-89-5)
- 3,3-Difluorospiro[3.3]heptane-1-carboxylic acid (CAS 2680529-49-9)
- 5-Chloro-N-methoxy-N-methylthiophene-2-carboxamide (CAS 288392-18-7)
- (2Z)-2-(4-Chlorobenzenesulfonyl)-1-(4-chlorophenyl)-3-(dimethylamino)prop-2-en-1-one (CAS 1164563-97-6)
- 1-(7-(2-Chlorophenyl)-1,4-thiazepan-4-yl)-2-(thiophen-3-yl)ethan-1-one (CAS 1795302-34-9)
- 2-(Benzo[d]thiazol-2-yl)-3-mercapto-3-((3-methoxyphenyl)amino)acrylonitrile (CAS 379255-68-2)
- 4-Chloro-5-((2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)amino)-2-ethylpyridazin-3(2H)-one (CAS 320421-66-7)
- 2-Fluoro-6-(4-methylpiperidin-1-yl)pyridine (CAS 1249647-13-9)
- Semaglutide impurity 273 (CAS CATO-C4X-2226273)
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