5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite CAS 142808-44-4
| CAS No. | 142808-44-4 |
| Molecular Formula | C46H50F2N5O8P |
| Molecular Weight | 869.89 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite (CAS 142808-44-4) is a high-purity analytical reference standard with the molecular formula C46H50F2N5O8P and a molecular weight of 869.89 g/mol.
The molecular framework of 5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite (C46H50F2N5O8P) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C46H50F2N5O8P |
| Molecular Weight | 869.89 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 23.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
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