cis-Montelukast Sulfoxide CAS 1428511-42-5
| CAS No. | 1428511-42-5 |
| Molecular Formula | C35H36ClNO4S |
| Molecular Weight | 602.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
cis-Montelukast Sulfoxide (CAS 1428511-42-5), molecular formula C35H36ClNO4S and molecular weight 602.19 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of cis-Montelukast Sulfoxide (C35H36ClNO4S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), cis-Montelukast Sulfoxide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C35H36ClNO4S |
| Molecular Weight | 602.19 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related cis Standards
- Montelukast R-Sulfoxide (CAS 1152185-58-4)
- Montelukast EP Impurity I (CAS 184763-26-6)
- Montelukast 1,2-Diol (Mixture of Diastereomers) (CAS 186352-97-6)
- Montelukast - Impurity C (sodium Salt) (CAS 909796-71-0)
- Montelukast Hydroxy (CAS 679838-32-5)
- Montelukast EP Impurity I (CAS 2045402-27-3)
- Montelukast Impurity 23 (CAS CATO-C4X-103123)
- Montelukast EP Impurity C(Mixture of Diastereomers) (CAS 909849-96-3)
Recommended Standards
- Montelukast Impurity 59 (CAS CATO-C4X-103159)
- 2,6,10-Tribromo-4,4,8,8,12,12-hexamethyl-4H,8H,12H-benzo[1,9]quinolizino[3,4,5,6,7-defg]acridine (CAS 928642-02-8)
- Montelukast Impurity 46 (CAS CATO-C4X-103146)
- Macitentan Impurity 27 (CAS CATO-C4X-117527)
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