Fezolinetant impurity 2 CAS 1429558-79-1
| CAS No. | 1429558-79-1 |
| Molecular Formula | C18H22N6O2S |
| Molecular Weight | 386.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Fezolinetant impurity 2 is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Fezolinetant impurity 2 (CAS 1429558-79-1, C18H22N6O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Fezolinetant impurity 2 (C18H22N6O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Fezolinetant impurity 2 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H22N6O2S |
| Molecular Weight | 386.47 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Fezolinetant Standards
- Fezolinetant Impurity 23 (CAS CATO-C4X-327023)
- Fezolinetant Impurity 6 (CAS 2759134-53-5)
- Fezolinetant Impurity 31 (CAS CATO-C4X-327031)
- Fezolinetant Impurity 30 (CAS CATO-C4X-327030)
- Fezolinetant Impurity 26 (CAS CATO-C4X-327026)
- Fezolinetant Impurity 18 (CAS CATO-C4X-327018)
- Fezolinetant Impurity 11 (CAS CATO-C4X-327011)
- Fezolinetant (CAS 1629229-37-3)
Recommended Standards
- Axitinib Impurity 84 (CAS CATO-C4X-107184)
- Axitinib Impurity 60 (CAS CATO-C4X-107160)
- Boc-His-Met-OH (CAS 248921-84-8)
- Axitinib Impurity 3 (CAS 885126-40-9)
- N-Nitroso Linagliptin Impurity 112 (CAS CATO-C4X-1101112)
- Ticagrelor Impurity 150 (CAS 220349-80-4)
- Cefcapene Impurity 88 (CAS CATO-C4X-182488)
- (S)-1-(Pyridin-4-yl)propan-1-aminehydrochloride (CAS 1311254-93-9)
- Naquotinib (CAS 1448232-80-1)
- Allopseudococaine Hydrochloride (CAS 109582-53-8)
- Acetic acid, 2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)oxy]-, 2,5-dioxo-1-pyrrolidinyl ester (CAS 1333377-78-8)
- N-([1,1'-Biphenyl]-2-yl)-2-((3-ethyl-4-oxo-3,4,5,6,7,8-hexahydrobenzo[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 577789-79-8)
- 5-Amino-1-[5-(trifluoromethyl)pyridin-2-yl]-1h-pyrazol-3-ol (CAS 1291984-65-0)
- 59880-97-6 Chemotactic peptide F-Met-Leu-Phe L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)- N-Formyl-L-methionyl-L-leucyl-L-phenylalanine N-Formyl-Met-Leu-Phe N-Formylmethionine leucyl-phenylalanine fMLF fMLP (misnomer but widely used) (CAS 59880-97-6)
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