4-(Benzyloxy)-2,3-difluorobenzoic acid CAS 144292-54-6
| CAS No. | 144292-54-6 |
| Molecular Formula | C14H10F2O3 |
| Molecular Weight | 264.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 4-(Benzyloxy)-2,3-difluorobenzoic acid (CAS 144292-54-6), a certified reference material (molecular formula C14H10F2O3, MW 264.22 g/mol) for analytical method development and quality control.
The molecular framework of 4-(Benzyloxy)-2,3-difluorobenzoic acid (C14H10F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 4-(Benzyloxy)-2,3-difluorobenzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H10F2O3 |
| Molecular Weight | 264.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
Related Benzyloxy Standards
- 4-(Benzyloxy)-3,5-difluorobenzoic acid (CAS 1408143-67-8)
- 3-(Benzyloxy)-2,6-difluorobenzoic acid (CAS 1421604-28-5)
- 4-(Benzyloxy)-2,5-difluorobenzoic acid (CAS 158905-26-1)
- 3-(Benzyloxy)-2,4-difluorobenzoic acid (CAS 1637224-62-4)
- 2-(Benzyloxy)-4,5-difluorobenzoic acid (CAS 1823862-15-2)
- 2-(Benzyloxy)-3,4-difluorobenzoic acid (CAS 2276098-34-9)
- 4-Benzyloxy-2,6-difluorobenzoic acid (CAS 335140-79-9)
- (R)-3-((Benzyloxy)carbonyl)-2-oxoimidazolidine-4-carboxylicacid (CAS 634614-25-8)
Recommended Standards
- 1-(2-Butoxy-5-fluorophenyl)-2,2,2-trifluoroethan-1-one (CAS 1443302-95-1)
- 1-(3-Butoxy-5-fluorophenyl)-2,2,2-trifluoroethan-1-one (CAS 1443305-64-3)
- 2-Fluoro-4-(3-fluoro-5-methoxyphenyl)benzoic acid (CAS 1365272-82-7)
- 2,2,2-Trifluoro-1-(3-fluoro-4-isobutoxyphenyl)ethanone (CAS 1443307-57-0)
- 2-Methoxy-5-(trifluoromethoxy)benzoic acid (CAS 191604-88-3)
- 1-(3-methoxybenzoyl)piperidin-4-one (CAS 1016741-90-4)
- Ethyl Maltol-d5 (CAS CATO-CCFD201836)
- Ethyl 2,2-dihydroxyacetate (CAS 64805-08-9)
- 2-Iodo-3,5-dimethylpyridine (CAS 445373-09-1)
- 1-(4-methylphenyl)butan-2-amine (CAS 147702-26-9)
- 4,5,6,7-Tetrahydro-1H-pyrrolo[2,3-b]pyridine (CAS 858274-68-7)
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- 103244-41-3 Insulin-like Growth Factor-II fragment 33-40 Ser-Arg-Val-Ser-Arg-Arg-Ser-Arg (CAS 103244-41-3)
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