Ethyl 4,7-dichloro-6-(difluoromethoxy)quinoline-3-carboxylate CAS 1443288-81-0
| CAS No. | 1443288-81-0 |
| Molecular Formula | C13H9Cl2F2NO3 |
| Molecular Weight | 336.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Ethyl 4,7-dichloro-6-(difluoromethoxy)quinoline-3-carboxylate (CAS 1443288-81-0) is a high-purity analytical reference standard with the molecular formula C13H9Cl2F2NO3 and a molecular weight of 336.12 g/mol.
Structurally, Ethyl 4,7-dichloro-6-(difluoromethoxy)quinoline-3-carboxylate (C13H9Cl2F2NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 336.12 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 4,7-dichloro-6-(difluoromethoxy)quinoline-3-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9Cl2F2NO3 |
| Molecular Weight | 336.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Ethyl Standards
- 1-(2,6-Dichloro-4-(trifluoromethyl)phenyl)-2,5-dimethyl-1H-pyrrole-3-carbaldehyde (CAS 144890-91-5)
- 2-[(3,7-dichloro-8-quinolyl)carbonyl]cyclohexane-1,3-dione (CAS 130901-36-8)
- 2-(2,5-Dichloro-4-nitrophenyl)-3,4-dihydronaphthalen-1(2H)-one (CAS 1451449-41-4)
- 2-(3,5-Dichloro-4-hydroxyphenethyl)isoindoline-1,3-dione (CAS 889651-04-1)
- 3-(5,6-Dichloro-1H-indol-2-yl)-4-methoxybenzoic acid (CAS 835595-00-1)
- 2,2-Dichloro-1,1-bis(4-chlorophenyl)ethanol (CAS 3567-18-8)
- 3-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzoic acid (CAS 543737-13-9)
- (2E)-2,3-Dichloro-N-(2-methylphenyl)-3-(propane-2-sulfonyl)prop-2-enamide (CAS 861211-89-4)
Recommended Standards
- 4,5-Diethoxy-2-iodobenzoic acid (CAS 133682-08-3)
- 3-Iodo-5-methoxy-4-propoxybenzoic acid (CAS 145399-74-2)
- 4-(2-Ethoxyethoxy)-3-iodobenzoic acid (CAS 1131614-52-2)
- 7-Iodo-9H-fluorene-4-carboxylic acid (CAS 16218-33-0)
- 5-Cyano-2-methyl-benzenesulfonylchloride (CAS 372198-49-7)
- B-[6-(9-Phenanthrenyl)-2-naphthalenyl]boronic acid (CAS 1096686-57-5)
- 2-(2-Piperidinyl)ethyl cyclobutanecarboxylatehydrochloride (CAS 1220038-28-7)
- 4-Imino-6,8-dimethyl-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid (CAS 61559-91-9)
- (E)-N,N-Dimethyl-4-(2-(pyrazin-2-yl)vinyl)aniline (CAS 502846-06-2)
- 2-(1H-1,3-Benzodiazol-2-yl)-4-methylaniline (CAS 10173-57-6)
- 3-Chloro-2-fluoro-4-nitrophenol (CAS 1805115-08-5)
- 3-Amino-3-(1-(tert-butoxycarbonyl)piperidin-3-yl)propanoic acid (CAS 372144-08-6)
- 3-(4-(4H-1,2,4-triazol-4-yl)phenyl)propanoic acid (CAS 924861-83-6)
- Insulin Degludec Impurity 10 (CAS CATO-C4X-215710)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com