5'-Fluoro-2'-methoxy-[1,1'-biphenyl]-3-thiol CAS 1443306-46-4
| CAS No. | 1443306-46-4 |
| Molecular Formula | C13H11FOS |
| Molecular Weight | 234.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5'-Fluoro-2'-methoxy-[1,1'-biphenyl]-3-thiol (CAS 1443306-46-4) is a high-purity analytical reference standard with the molecular formula C13H11FOS and a molecular weight of 234.29 g/mol.
The molecular framework of 5'-Fluoro-2'-methoxy-[1,1'-biphenyl]-3-thiol (C13H11FOS) is characterized by sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H11FOS |
| Molecular Weight | 234.29 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
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