Ethyl 2-(3-ethoxy-4,5-difluorophenyl)-2-oxoacetate CAS 1443324-49-9
| CAS No. | 1443324-49-9 |
| Molecular Formula | C12H12F2O4 |
| Molecular Weight | 258.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 258.22 g/mol gives Ethyl 2-(3-ethoxy-4,5-difluorophenyl)-2-oxoacetate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Ethyl 2-(3-ethoxy-4,5-difluorophenyl)-2-oxoacetate (CAS 1443324-49-9), a certified reference material (molecular formula C12H12F2O4, MW 258.22 g/mol) for analytical method development and quality control.
The molecular framework of Ethyl 2-(3-ethoxy-4,5-difluorophenyl)-2-oxoacetate (C12H12F2O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H12F2O4 |
| Molecular Weight | 258.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
Related Ethyl Standards
- Ethyl 2-(4-ethoxy-3,5-difluorophenyl)-2-oxoacetate (CAS 1443304-69-5)
- Ethyl 2-(2-ethoxy-3,5-difluorophenyl)-2-oxoacetate (CAS 1443327-39-6)
- Methyl 2-(2-ethoxy-1,1-difluoro-2-oxoethyl)benzoate (CAS 1835726-67-4)
- 7-Ethoxy-4-(trifluoromethyl)coumarin (CAS 115453-82-2)
- Methyl 3-[(1-ethoxy-1-oxopropan-2-yl)oxy]thiophene-2-carboxylate (CAS 866009-07-6)
- Ethyl 4-(2-ethoxy-1-methyl-2-oxoethyl)piperazine-1-carboxylate (CAS 856843-19-1)
- (1-Ethoxy-2,2,2-trifluoroethoxy)triethylsilane (CAS 1254592-76-1)
- 4'-Ethoxy-4-propyl-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one (CAS 177652-31-2)
Recommended Standards
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- 1-(4-Nitrophenyl)-1,4-diazepane (CAS 214124-83-1)
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- (2-(4-(Trifluoromethyl)phenyl)thiazole-4,5-diyl)dimethanol (CAS 444615-64-9)
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