2-(2-(3-Chloro-2-fluorophenoxy)ethyl)-1,3-dioxane CAS 1443336-74-0
| CAS No. | 1443336-74-0 |
| Molecular Formula | C12H14ClFO3 |
| Molecular Weight | 260.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-(2-(3-Chloro-2-fluorophenoxy)ethyl)-1,3-dioxane (CAS 1443336-74-0), molecular formula C12H14ClFO3 and molecular weight 260.69 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(2-(3-Chloro-2-fluorophenoxy)ethyl)-1,3-dioxane (C12H14ClFO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H14ClFO3 |
| Molecular Weight | 260.69 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 2-Chloro-1-(3-fluorobenzyl)-1H-benzo[d]imidazole (CAS 1353979-32-4)
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