Ethyl 3-(2-chloro-5-fluorophenoxy)propanoate CAS 1443347-66-7
| CAS No. | 1443347-66-7 |
| Molecular Formula | C11H12ClFO3 |
| Molecular Weight | 246.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies Ethyl 3-(2-chloro-5-fluorophenoxy)propanoate (CAS 1443347-66-7), a certified reference material (molecular formula C11H12ClFO3, MW 246.66 g/mol) for analytical method development and quality control.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, Ethyl 3-(2-chloro-5-fluorophenoxy)propanoate is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 246.66 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12ClFO3 |
| Molecular Weight | 246.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
Related Ethyl Standards
- Ethyl 3-(2-chloro-4-fluorophenoxy)propanoate (CAS 1094502-56-3)
- Ethyl 3-(3-chloro-4-fluorophenoxy)propanoate (CAS 1099681-71-6)
- 5-Chloro-2-(3-fluorophenyl)benzofuran (CAS 1099813-16-7)
- 2-(2-(2-Chloro-4-fluorophenoxy)ethyl)-1,3-dioxolane (CAS 1226239-43-5)
- 3-(4-Chloro-3-ethoxy-2-fluorophenyl)propanoic acid (CAS 1323966-45-5)
- Ethyl 3-(4-chloro-2-fluorophenoxy)propanoate (CAS 1443304-73-1)
- Ethyl 3-(3-chloro-2-fluorophenoxy)propanoate (CAS 1443338-61-1)
- 2-(2-(4-Chloro-2-fluorophenoxy)ethyl)-1,3-dioxolane (CAS 1443338-63-3)
Recommended Standards
- 2-(2-(4-Chloro-3-fluorophenoxy)ethyl)-1,3-dioxolane (CAS 1443345-16-1)
- 2-(2-(2-Chloro-5-fluorophenoxy)ethyl)-1,3-dioxolane (CAS 1443354-09-3)
- 2-(2-(3-Chloro-4-fluorophenoxy)ethyl)-1,3-dioxolane (CAS 1443354-15-1)
- Ethyl 3-(4-chloro-3-fluorophenoxy)propanoate (CAS 1443354-26-4)
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- Semaglutide impurity 233 (CAS CATO-C4X-2226233)
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