2-(2-(2,6-Difluorophenoxy)ethyl)-1,3-dioxane CAS 1443353-58-9
| CAS No. | 1443353-58-9 |
| Molecular Formula | C12H14F2O3 |
| Molecular Weight | 244.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-(2-(2,6-Difluorophenoxy)ethyl)-1,3-dioxane (CAS 1443353-58-9), molecular formula C12H14F2O3 and molecular weight 244.23 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(2-(2,6-Difluorophenoxy)ethyl)-1,3-dioxane (C12H14F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H14F2O3 |
| Molecular Weight | 244.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
Related Difluorophenoxy Standards
- 2-(2-(3,5-Difluorophenoxy)ethyl)-1,3-dioxane (CAS 1443306-28-2)
- 2-(2-(3,4-Difluorophenoxy)ethyl)-1,3-dioxane (CAS 1443336-61-5)
- 2-(2-(2,4-Difluorophenoxy)ethyl)-1,3-dioxane (CAS 1443337-20-9)
- 2-(2-(2,5-Difluorophenoxy)ethyl)-1,3-dioxane (CAS 1443341-86-3)
- 2-(2-(2,3-Difluorophenoxy)ethyl)-1,3-dioxane (CAS 1443344-95-3)
- Ethyl 2-(2,4-difluorophenoxy)butanoate (CAS 1494494-18-6)
- 1-(3,4-Difluorophenoxy)-3-(isopropylamino)propan-2-ol (CAS 1153086-81-7)
- Methyl 3-(3,5-difluorophenoxy)-2-hydroxy-2-methylpropanoate (CAS 1480951-74-3)
Recommended Standards
- 3-(2,6-Difluoro-4-methoxyphenyl)-3-methylbutanoic acid (CAS 1502750-89-1)
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- 2-(3-Butoxy-2,6-difluorophenyl)acetic acid (CAS 1706446-28-7)
- Thiophen-3-yl(3,4,5-trifluorophenyl)methanol (CAS 1443312-40-0)
- 6-Ethoxy-N-methylbenzo[d]thiazol-2-amine (CAS 71720-53-1)
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- H-Tyr-Tyr-Tyr-OMe (CAS 53566-70-4)
- 4-(Bromomethyl)furan-2(5H)-one (CAS 61934-55-2)
- Benzyl 4-iodobutanoate (CAS 118058-69-8)
- 6-(3-(Trifluoromethyl)phenyl)pyrimidin-4-amine (CAS 1482437-88-6)
- 4-Amino-2-(morpholin-4-ylmethyl)phenol (CAS 76226-59-0)
- 1,3-Dimethyl-5-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)pyrimidine-2,4,6(1H,3H,5H)-trione (CAS 2027542-98-7)
- 210644-48-7 Anthranilyl-HIV Protease Substrate V (CAS 210644-48-7)
- Semaglutide Impurity 146 (CAS 2645421-68-5)
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