2-(Chloromethyl)-6,7-dimethoxyquinazolin-4-amine CAS 1443358-77-7
| CAS No. | 1443358-77-7 |
| Molecular Formula | C11H12ClN3O2 |
| Molecular Weight | 253.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-(Chloromethyl)-6,7-dimethoxyquinazolin-4-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 2-(Chloromethyl)-6,7-dimethoxyquinazolin-4-amine (CAS 1443358-77-7), a certified reference material (molecular formula C11H12ClN3O2, MW 253.68 g/mol) for analytical method development and quality control.
2-(Chloromethyl)-6,7-dimethoxyquinazolin-4-amine (C11H12ClN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C11H12ClN3O2 |
| Molecular Weight | 253.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloromethyl Standards
- 2-(Chloromethyl)-5-(2,5-dimethoxyphenyl)oxazole (CAS 1094318-29-2)
- Methyl 6-(chloromethyl)-1,4-dimethyl-1h-pyrazolo[3,4-b]pyridine-5-carboxylate (CAS 1375474-41-1)
- 3-(Chloromethyl)-5-(3,4-dimethoxyphenyl)isoxazole (CAS 934107-65-0)
- Ethyl 7-(chloromethyl)-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate (CAS 439110-66-4)
- 4-[4-(chloromethyl)-1,3-thiazol-2-yl]benzoic acid (CAS 842137-56-8)
- 6-(Chloromethyl)-2-n-(4-fluorophenyl)-1,3,5-triazine-2,4-diamine (CAS 105704-32-3)
- 5-(Chloromethyl)-n-phenyl-1,3,4-thiadiazole-2-carboxamide (CAS 113940-13-9)
- 3(S)-Chloromethyl-pyrrolidine-1-carboxylic acid benzyl ester (CAS 1187927-26-9)
Recommended Standards
- 2-(3-((2-Chlorophenoxy)methyl)-1,2,4-oxadiazol-5-yl)ethan-1-amine (CAS 1435804-76-4)
- 2-(3-Chloro-4-nitrophenyl)cyclohexan-1-one (CAS 1451450-58-0)
- 1-(2-(4-Chlorophenyl)acetyl)azetidine-3-carboxylic acid (CAS 1408485-12-0)
- Methyl 2-(2-chloro-5-methoxy-1H-indol-3-yl)acetate (CAS 164083-69-6)
- 4-Chloro-6-fluoro-2-phenylquinazoline (CAS 885277-09-8)
- 4-(3,5-Dichloropyrazin-2-yl)bicyclo[2.2.1]Heptane-1-carboxylic acid (CAS 2199982-85-7)
- N-(4-Methoxyphenethyl)-3,4-dimethylaniline (CAS 356537-73-0)
- (1R,2R)-2-((tert-Butyldimethylsilyl)oxy)cyclopentan-1-amine (CAS 2806011-38-9)
- Pyrantel EP Impurity B (CAS 36700-39-7)
- 1-(Pyrimido[5,4-e][1,2,4]triazin-5-yl)guanidine (CAS 21309-00-2)
- 4-Bromo-7-methylbenzo[d]thiazol-2-amine (CAS 942473-99-6)
- Methyl 3-fluoro-5-(3-methoxyphenyl)benzoate (CAS 1820651-05-5)
- 1-(4-Fluorobenzyl)-1-methylguanidine sulfate (CAS 1185037-72-2)
- Allo-D-Ile27-Tirzepatide (CAS CATO-CPTD788961)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com