6-bromo-4-fluoro-2H-isoquinolin-1-one CAS 1443377-43-2
| CAS No. | 1443377-43-2 |
| Molecular Formula | C9H13BrFNO |
| Molecular Weight | 250.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
6-bromo-4-fluoro-2H-isoquinolin-1-one (CAS 1443377-43-2), molecular formula C9H13BrFNO and molecular weight 250.11 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, 6-bromo-4-fluoro-2H-isoquinolin-1-one is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 250.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 6-bromo-4-fluoro-2H-isoquinolin-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H13BrFNO |
| Molecular Weight | 250.11 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- 4-(4-(Benzyloxy)-2-methylbenzoyl)-5-(3-bromophenyl)-3-hydroxy-1-(2-methoxyethyl)-1H-pyrrol-2(5H)-one (CAS 488853-85-6)
- 2,4,6-Trichlorophen-3,5-d2-ol (CAS 93951-80-5)
- 5,6-Dimethyl-2-(thiophen-2-yl)-1H-benzo[d]imidazole (CAS 4048-07-1)
- 3-AMino-4-hydroxy-5-methyl-benzoic acid methyl ester (CAS 861315-62-0)
- 2-(4-tert-Butylphenoxy)propanoyl chloride (CAS 431046-87-6)
- Semaglutide Impurity 183 (CAS 159541-28-3)
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