(2R,4S)-2-(2,5-Difluorophenyl)-4-fluoropyrrolidine hydrochloride CAS 1443538-52-0
| CAS No. | 1443538-52-0 |
| Molecular Formula | C10H10F3N |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies (2R,4S)-2-(2,5-Difluorophenyl)-4-fluoropyrrolidine hydrochloride (CAS 1443538-52-0), a certified reference material (molecular formula C10H10F3NHCl, MW 237.65 g/mol) for analytical method development and quality control.
(2R,4S)-2-(2,5-Difluorophenyl)-4-fluoropyrrolidine hydrochloride (C10H10F3NHCl) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10F3N HCl |
| Molecular Weight | 237.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 1-Vinyl-1,3-dihydroisobenzofuran (CAS 32521-09-8)
- Iridin (CAS 491-74-7)
- Tolmetin-d3 Ethyl Ester (CAS 1215579-60-4)
- N-Nitroso Vilazodone Impurity 10 (CAS CATO-C4X-135510)
- 2-Pentylheptan-1-ol (CAS 6345-85-3)
- 2-(3-(Pyridin-2-yl)-1H-pyrazol-1-yl)acetonitrile (CAS 262449-14-9)
- 4,8-Dimethyl-2-(pyrrolidin-1-yl)quinoline (CAS 338415-81-9)
- 1H-inden-1-one, 2,3-dihydro-2,5-dimethyl- (CAS 89044-48-4)
- 7-Hydroxy-3-(4-isopropylphenoxy)-2-methyl-4h-chromen-4-one (CAS 201284-88-0)
- Insulin Degludec Impurity 20 (CAS CATO-C4X-215720)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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