1-(Tert-butyl) 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate hydrochloride CAS 144527-44-6

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(Tert-butyl) 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate hydrochloride.

1-(Tert-butyl) 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate hydrochloride (CAS 144527-44-6), molecular formula C11H19NO5HCl and molecular weight 281.73 g/mol, is a CATO reference standard with documented purity and traceability.

Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, 1-(Tert-butyl) 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate hydrochloride is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 281.73 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 1-(Tert-butyl) 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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