Perindopril Impurity 10 CAS 144540-75-0
| CAS No. | 144540-75-0 |
| Molecular Formula | C9H15NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Perindopril Impurity 10 is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Perindopril Impurity 10 (CAS 144540-75-0, C9H15NO2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Perindopril Impurity 10 (C9H15NO2HCl) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 2.0, corresponding to approximately 2 ring(s) or double-bond equivalent(s). With a molecular weight of 205.68 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Perindopril Impurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H15NO2 HCl |
| Molecular Weight | 205.68 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Perindopril Standards
- Perindopril Impurity N3 (CAS 1004292-98-1)
- Perindopril T-Butylamine (CAS 107133-36-8)
- Perindopril Impurity N1 (CAS 108507-42-2)
- Perindopril Impurity 1 HCl (CAS 111013-52-6)
- Perindopril EP Impurity L (CAS 111836-22-7)
- Perindopril Acyl-beta-D-Glucuronide (CAS 120398-66-5)
- Perindopril Benzyl Ester (CAS 122454-52-8)
- Perindopril EP Impurity F (CAS 129970-98-5)
Recommended Standards
- Moxifloxacin Impurity 54 (CAS CATO-C4X-107454)
- Leuprorelin EP Impurity J Acetate (CAS CATO-C4X-182228)
- Tadalafil Impurity 85 (CAS 7479-05-2)
- 3,4-Bis(2-methylbutyloxy)benzeneboronicacid (CAS 340148-67-6)
- Dodeca-5,7-diyne-1,12-diol (CAS 74602-32-7)
- 6,6-Difluoro-5-hexen-2-one (CAS 76083-55-1)
- 6-Bromo-2-iodo-5-methoxy-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1227270-99-6)
- 5-Chloro-1-((2R,4R,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (CAS 188559-94-6)
- Bis((5-fluoropyridin-3-yl)methyl)amine hydrochloride (CAS 1951439-24-9)
- HA Peptide (CAS 92000-76-5)
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