2-Chloro-5-hydroxyisonicotinonitrile CAS 1445968-07-9
| CAS No. | 1445968-07-9 |
| Molecular Formula | C6H3ClN2O |
| Molecular Weight | 154.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Chloro-5-hydroxyisonicotinonitrile (C6H3ClN2O) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
2-Chloro-5-hydroxyisonicotinonitrile (CAS 1445968-07-9), molecular formula C6H3ClN2O and molecular weight 154.55 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Chloro-5-hydroxyisonicotinonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H3ClN2O |
| Molecular Weight | 154.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 5-Chloro-2-hydroxynicotinonitrile (CAS 1048913-62-7)
- 6-Chloro-5-hydroxynicotinonitrile (CAS 1187191-02-1)
- 3-Chloro-5-isocyanatopyridine (CAS 1260672-74-9)
- 3-Chloro-5-hydroxypicolinonitrile (CAS 1262860-70-7)
- 2-Chloro-6-hydroxypyridine-4-carbonitrile (CAS 1556812-05-5)
- 4-Chloro-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 1611464-71-1)
- 5-Chloro-4-oxo-1,4-dihydropyridine-3-carbonitrile (CAS 1708250-63-8)
- 6-Chloro-5-hydroxypicolinonitrile (CAS 1782056-32-9)
Recommended Standards
- 5-Chlorooxazolo[5,4-b]pyridine (CAS 1393546-57-0)
- 4-Chlorofuro[2,3-d]pyridazine (CAS 14757-81-4)
- 7-Chlorofuro[2,3-d]pyridazine (CAS 14757-89-2)
- 2-Chlorooxazolo[4,5-c]pyridine (CAS 1509638-12-3)
- 6-(4-Methyl-2-phenylthiazol-5-yl)pyridazin-3-ol (CAS 1105195-28-5)
- 2-((1-(3-Bromophenyl)ethyl)amino)ethan-1-ol (CAS 1038306-72-7)
- S-(2-Succinyl)-L-cysteine, >98% (CAS 547764-73-8)
- 8-(Trifluoromethoxy)quinolin-3-ol (CAS 1261886-64-9)
- 4-(Tert-butyl)-1-oxaspiro[2.5]octane (CAS 1496337-90-6)
- Methyl 2-Hydroxy-3-phenylpropanoate (CAS 13674-16-3)
- 1-Amino-N-isopropylcyclopropane-1-carboxamide (CAS 1489072-92-5)
- 1,1'-Bis(di-i-propylphosphino)ferrocene 97239-80-0 1,1'-BIS(DI-I-PROPYLPHOSPHINO)FERROCENE;1,1'-BIS(DIISOPROPYLPHOSPHINO)FERROCENE;BIS[(DIISOPROPYLPHOSPHINO)CYCLOPENTADIENYL]IRON;D-I-PRPF;DIPPF SC11315 (CAS 97239-80-0)
- 5-(2,4-difluorophenoxymethyl)-1,2-oxazole-3-carboxylic acid (CAS 932917-90-3)
- Semaglutide impurity 46 (CAS CATO-C4X-222646)
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