3-Bromo-4-fluorobenzenesulfonamide CAS 1446237-76-8
| CAS No. | 1446237-76-8 |
| Molecular Formula | C6H5BrFNO2S |
| Molecular Weight | 254.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
3-Bromo-4-fluorobenzenesulfonamide (CAS 1446237-76-8), molecular formula C6H5BrFNO2S and molecular weight 254.08 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Bromo-4-fluorobenzenesulfonamide (C6H5BrFNO2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 3-Bromo-4-fluorobenzenesulfonamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H5BrFNO2S |
| Molecular Weight | 254.08 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
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Recommended Standards
- 5-Bromo-3-fluoro-2-(methylsulfonyl)pyridine (CAS 1446002-35-2)
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- 6-Bromo-N-methyl-1H-indazole-3-carboxamide (CAS 1445966-92-6)
- 2-Amino-5-bromo-6-methylquinazolin-4(1H)-one (CAS 147149-89-1)
- 2-(2,5-Dimethylbenzoyl)benzoic acid (CAS 60288-22-4)
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- 3-Cyclopropoxy-4-ethyl-5-isopropoxypyridine (CAS 1243287-77-5)
- 2-Fluoro-3,4-dimethylbenzaldehyde (CAS 363134-38-7)
- 2-(Methoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (CAS 110599-67-2)
- 3-Chloro-4-((3-fluorobenzyl)oxy)benzohydrazide (CAS 1706446-41-4)
- 2,2,2-Trifluoro-1-(thiophen-2-yl)ethan-1-amine (CAS 65686-95-5)
- 1-(4-Methoxyphenyl)-2-methylprop-2-en-1-one (CAS 6230-72-4)
- 3-[3-(3,4-Dichlorophenyl)-3-piperidinyl]-1-propanol (CAS 182621-51-8)
- Semaglutide impurity 94 (CAS CATO-C4X-222694)
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