Ethyl 2-(3,5-bis(trifluoromethyl)phenyl)acetate CAS 144632-97-3
| CAS No. | 144632-97-3 |
| Molecular Formula | C12H10F6O2 |
| Molecular Weight | 300.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 2-(3,5-bis(trifluoromethyl)phenyl)acetate.
Ethyl 2-(3,5-bis(trifluoromethyl)phenyl)acetate (CAS 144632-97-3), molecular formula C12H10F6O2 and molecular weight 300.20 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 2-(3,5-bis(trifluoromethyl)phenyl)acetate (C12H10F6O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H10F6O2 |
| Molecular Weight | 300.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
Recommended Standards
- 4,4-Dimethyl-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydronaphthalen-1(2H)-one (CAS 1312464-78-0)
- Ethyl 2,6-Bis(trifluoromethyl)phenylacetate (CAS 1807227-65-1)
- Perfluorophenyl 2-(acetylthio)acetate (CAS 129815-48-1)
- 1-(2-Methylpropyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole (CAS 1815595-36-8)
- 2-(1-oxo-1H-isochromen-3-yl)acetic acid (CAS 39153-95-2)
- ON-123300 (CAS 1357470-29-1)
- 4-Ethynyl-1,5-dimethyl-1H-pyrazole (CAS 61514-54-3)
- Methyl 2-(3-bromopyridin-2-yl)acetate (CAS 192642-95-8)
- Tricosan-2-one (CAS 7320-54-9)
- 3-Cyano-4,5-difluorobenzoic acid (CAS 1783727-59-2)
- (2S,3S)-3-((tert-butoxycarbonyl)amino)-3-(3,5-dimethoxyphenyl)-2-hydroxypropanoic acid (CAS 959577-97-0)
- N-Butyl-3-chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)benzamide (CAS 898425-40-6)
- 2-(4-Chlorophenyl)spiro[3.3]Heptane-2-carboxylic acid (CAS 1466868-77-8)
- Tirzepatide Impurity 13 (CAS CATO-C4X-324013)
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