1-Cyclopropyl-3-(2,6-difluorophenyl)-1-(2-(thiophen-2-yl)ethyl)urea CAS 1448129-61-0
| CAS No. | 1448129-61-0 |
| Molecular Formula | C16H16F2N2OS |
| Molecular Weight | 322.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-Cyclopropyl-3-(2,6-difluorophenyl)-1-(2-(thiophen-2-yl)ethyl)urea.
1-Cyclopropyl-3-(2,6-difluorophenyl)-1-(2-(thiophen-2-yl)ethyl)urea (CAS 1448129-61-0) is a high-purity analytical reference standard with the molecular formula C16H16F2N2OS and a molecular weight of 322.37 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution, 1-Cyclopropyl-3-(2,6-difluorophenyl)-1-(2-(thiophen-2-yl)ethyl)urea is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 322.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-Cyclopropyl-3-(2,6-difluorophenyl)-1-(2-(thiophen-2-yl)ethyl)urea meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H16F2N2OS |
| Molecular Weight | 322.37 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 6-(hydroxymethyl)-2-methyl-pyridazin-3-one (CAS 1257242-88-8)
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- Cycloocta[f]isobenzofuran-1,3-dione (CAS 28979-93-3)
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyrimidine (CAS 1351234-12-2)
- Methyl 2-(4-hydroxy-1-((5-methylfuran-2-yl)methyl)-2-oxo-1,2-dihydropyridin-3-yl)acetate (CAS 477864-38-3)
- H-D-Phe-D-Phe-D-Leu-D-Lys-γ-Pip-D-Phe-D-Phe-D-Leu-D-Lys-γ-Pip-OH (CAS CATO-CPTD788717)
- 4-Bromo-3-methylphenethylamine (CAS 786625-94-3)
- Pyrrolo[1,2-a]thieno[2,3-e]pyrazin-5-amine (CAS 111886-59-0)
- 4-(3-Chlorophenyl)piperazine-1-sulfonamide (CAS 869843-51-6)
- Insulin Degludec Impurity 26 (CAS CATO-C4X-215726)
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