8-Amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide CAS 1449277-10-4
| CAS No. | 1449277-10-4 |
| Molecular Formula | C22H20FN5O2 |
| Molecular Weight | 405.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 8-Amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
8-Amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide (CAS 1449277-10-4) is a high-purity analytical reference standard with the molecular formula C22H20FN5O2 and a molecular weight of 405.42 g/mol.
The molecular framework of 8-Amino-N-(1-(cyclopropanecarbonyl)azetidin-3-yl)-2-(3-fluorophenyl)-1,7-naphthyridine-5-carboxamide (C22H20FN5O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H20FN5O2 |
| Molecular Weight | 405.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Amino Standards
- 6-Amino-2-(benzylthio)-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purine 1-oxide (CAS 64570-11-2)
- 3-Amino-N-(p-tolyl)-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 626227-84-7)
- 6-Amino-N-[(4-methylphenyl)methyl]-8-(trifluoromethyl)-4-thia-2-azatricyclo[7.3.0.0^{3,7}]dodeca-1(9),2,5,7-tetraene-5-carboxamide (CAS 664999-45-5)
- 6-Amino-N-[2-(trifluoromethyl)phenyl]-4-thia-2-azatricyclo[7.5.0.0^{3,7}]tetradeca-1(9),2,5,7-tetraene-5-carboxamide (CAS 387831-27-8)
- Benzyl (2-((2-amino-4-methoxyphenyl)(phenyl)amino)-2-oxoethyl)carbamate (CAS 1381947-84-7)
- 1-Amino-4-((4-(phenylamino)phenyl)amino)anthracene-9,10-dione (CAS 88653-17-2)
- 1-Amino-5-hydroxy-4-((2-methoxyphenyl)amino)-8-nitroanthracene-9,10-dione (CAS 71412-38-9)
- 2-Amino-N-((1S,2R,3R,4S,5S,6R)-4-amino-3-(((2R,3R,6S)-3-amino-6-((S)-1-aminoethyl)tetrahydro-2H-pyran-2-yl)oxy)-2,5-dihydroxy-6-methoxycyclohexyl)-N-methylacetamide (CAS 55779-06-1)
Recommended Standards
- 4-(4-bromophenyl)-5-sulfanyl-8-thia-4,6-diazatricyclo[7.4.0.0²,⁷]trideca-1(9),2(7),5-trien-3-one (CAS 136386-74-8)
- 3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-fluorophenyl)propanoic acid (CAS 188814-36-0)
- Methyl (2Z)-3-[(2H-1,3-benzodioxol-5-yl)amino]-2-(4-ethoxybenzenesulfonyl)prop-2-enoate (CAS 1327196-24-6)
- (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluorophenyl)propanoic acid (CAS 511272-51-8)
- 4-(2-Hydroxyethyl)-2,6-dimethylbenzene-1,3-diol (CAS 101383-04-4)
- 4-Hydrazino-1-methylquinolin-2(1H)-one (CAS 192633-21-9)
- Acetonitrile-2-<SUP>13</SUP>C (CAS 1722-09-4)
- (S)-6-(3-(tert-Butyl)-5-(3-(2,3-dichlorophenyl)ureido)-1H-pyrazol-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (CAS 897369-18-5)
- N-Nitroso Alfuzosin (CAS CATO-C4X-15369)
- tert-Butyl (cis-4-(cyanomethyl)cyclohexyl)carbamate (CAS 1461718-35-3)
- Ipidacrine Hydrochloride Hydrate (CAS 118499-70-0)
- N-(2,5-dichlorophenyl)-2-hydrazinyl-2-oxoacetamide (CAS 443863-61-4)
- 5,6-Dihydroxycyclohex-5-ene-1,2,3,4-tetraone (CAS 118-76-3)
- (Des-Thr?)-Glucagon trifluoroacetate salt (CAS 1802078-27-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com